Main research interests: tumor immunity and molecular biology.
In recent years, he has successively undertaken the Youth Fund of Shandong Provincial Health Department "APC, HMSH 1, the role of HMSH2 gene in the diagnosis and treatment of colon polyps and colon cancer" and the project "Molecular mechanism of malignant tumor metastasis" of Shandong Provincial Science and Technology Department. At present, it undertakes the National Natural Foundation of China's Research on Screening and Down-regulation Mechanism of Cervical Cancer-associated Virus Human Papillomavirus Subtype, Shandong Science and Technology Project "Study on Serum Differential Proteins in Diagnosis and Metastasis of Colorectal Cancer" and Shandong Science and Technology Department's International Cooperation Research Project "Study on the Molecular Relationship between HBV Infection and Host MHC-I", with a longitudinal research fund of 450,000 yuan. The research on the role of tumor surface and host MHC in the occurrence and metastasis of some solid tumors was awarded the second prize of National Science and Technology Progress Award, the third prize of Shandong Science and Technology Progress Award and the second prize of Shandong Medical Science and Technology Innovation Award 1 item recommended by the Ministry of Education. Editorial Board of Clinical Laboratory Immunology, the textbook of the 11th Five-Year Plan for national colleges and universities, the deputy editor of Medical Laboratory and Clinic, the training textbook for national specialists of the Department of Science and Education of the Ministry of Health, five books including Modern Laboratory Medical Technology and Quality Control, Laboratory and Clinical Nephropathy, and six books including Molecular Immunology and Clinic. In recent years, more than 40 academic papers and 6 SCI papers have been published in core journals at home and abroad. Among them, "The relationship between human papillomavirus 16E7 and HLA class antigen expression before forensic malignant transformation and malignant diseases" was awarded as an excellent paper at the 59th annual meeting of american association for clinical chemistry (AACC). In 2009, it is planned to recruit 2 doctoral students, who can work in hospital laboratories and scientific research institutions.
1. Screening of cervical cancer-associated virus human papillomavirus subtype and its mechanism research, National Natural Science Foundation, first place (80,000 yuan).
2. The first prize (654.38+ 10,000 yuan) of Shandong Medical and Health Outstanding Academic Leaders Fund. Study on the down-regulation mechanism of HLA-I molecules on cell membrane surface caused by human papillomavirus 16E7 gene.
3. The key scientific and technological project of Shandong Province "Study on Serum Differential Proteins in Diagnosis and Metastasis of Colorectal Cancer" won the first prize (1.2000 yuan).
4. Study on the application of HLA-I molecule in patients with hepatitis B virus infection, Shandong International Cooperation Project, first place (654.38+10,000 yuan).
5. Study on down-regulation mechanism of MHC-I molecule in cervical cancer caused by human papillomavirus, first prize of Shandong Natural Science Foundation (50,000 yuan)
1. Correlation between human papillomavirus 16 E7 and HLA class antigen expression in cervical precancerous lesions and malignant lesions. International Journal of Biomarkers 2007,22 (2):124-131(correspondent, included in SCI).
2. Using seldi-tof-ms to establish a serum protein model for screening color tumors. Experimental Oncology 2006,28 (4): 282-287 (correspondent, included in SCI).
3. The expression of HLA and ⅱ in peripheral blood diseases of 3.HBV infected people. (First author, included in SCI)
4. Screening the genotypes of human papillomavirus in high-risk population in Shandong by using liquid chip technology, China Journal of Epidemiology, 2007,28 (5): 487-490 (correspondent).
5. Establishment of real-time fluorescence quantitative PCR detection method for human papillomavirus E7 gene and its application value in the diagnosis of cervical diseases, Chinese Journal of Laboratory Medicine, 2007,30 30 (10/0) (correspondent)
6. Establishment of lymphocyte HLA-A mRNA methodology and its application in patients with HBV infection, Chinese Journal of Laboratory Medicine, 2006,29 (8): 708-710 (first author)
7. Detection of platelet particles, surface glycoprotein Ⅱ b-Ⅲ a and aggregation rate in elderly patients with thrombosis, Chinese Journal of Geriatrics, 2004,23 (6): 390-392 (first author)
8. Correlation between platelet microparticle detection and platelet membrane surface glycoprotein CD62P in 8.ITP patients. Chinese Journal of Medicine 2003,83 (21):1918-19 (first author).
Publish academic works
1. Modern Laboratory Medicine Technology and Quality Control, Shandong Science and Technology Press, 2004, the first editor.
2. Examination and Clinical Diagnosis of Nephropathy, People's Military Medical Publishing House, 2006, the first editor.
3. Medical Laboratory and Clinical Application, People's Medical Publishing House, 2008, deputy editor.
4. Clinical Laboratory Immunology, a textbook for the 11th Five-Year Plan, Higher Education Press, 2007, editorial board.
5. Molecular Immunology and Clinic, Shandong Science and Technology Press, 2003, Editorial Board.