Small base and relatively large base are words that people who lose weight often mention. Body base means that the balance of body index is poor, and small base means that the fat content is relatively small and the fat layer is thin.
Smoking:
In September, 20021,in a paper published in PLoS Genetics, researchers analyzed how genes and smoking affect individual body mass index based on the genome sequence numbers of 390,000 Britons. They found that genes can explain 50% difference in body mass index between individuals, and self-reported smoking can explain 2% difference in body mass index.
Because smoking can lead to DNA methylation (a biomarker), they found that 62 methylation sites related to smoking can explain the 22% difference in body mass index, which is far greater than the results obtained by self-report. This study shows that biomarkers may help to measure the impact of lifestyle and other factors on health more accurately.