Fisher thinks that biostatistics and various statistical methods in development have the potential to combine "discontinuous" Mendel's law (such as ABO blood group), "continuous" polygene inheritance (such as human skin color) and "gradual" Darwinian evolution theory. In addition, because of his interest in statistics, Fisher studied the papers published by two famous statisticians, karl pearson and William gossett (pen name "student"). The popular eugenics thought at that time was also a topic of concern to Fisher. He even regarded the population problem in society as a science including genetics and statistics. 19 1 1 year, together with some famous people at that time, such as economist Keynes, geneticist Bennett and engineer Horace Darwin (son of Charles Darwin), he founded the eugenics society of Cambridge University. This is an active group. They get together once a month and give speeches in other mainstream eugenics organizations. For example, Francis Galton established the Eugenics Education Society in 1909.
19 12, Fisher passed the mathematics degree exam and graduated from Cambridge University the following year. 19 14, World War I broke out. Fisher, like many British youths, also wants to join the army and go to war. However, because of his serious vision problems, even if he tries again, he still can't pass the health check. Because he failed to join the army, he worked as a statistician in London for the next six years and also taught physics and mathematics in several public schools. For example, Bradfield College in Berkshire. In addition, he once boarded the HMS Worcester, a teaching ship of the British Navy.
Leonard Darwin (another son of Charles Darwin), a major in the British army, and another friend whom Fisher called Goodluna were important pillars of his period, and their support helped him tide over the difficulties. Eileen Guinness, Goodluna's sister, met Fisher through Goodluna's introduction. 19 17, Irene married Fisher when she was only 17 years old. In addition, with the help of his sisters, Fisher established and operated a farm called Bradfield Manor, where they planted flower beds and raised animals. Because of the livelihood of this manor, they didn't need to receive government rations during the war.
During the First World War, Fisher began to write some review articles for a periodical, Eugenics Review, and gradually strengthened his interest in genetics and statistics during the writing process. After that, he volunteered to do all the review work for this magazine. In addition, Fisher was employed by Leonard Darwin to do temporary work.
At the same time, during this period, he also published many papers related to biostatistics, including the genetic relationship supported by Mendel's heredity. This paper was completed in 19 16 and published in 19 18. At the same time, genetics based on biostatistics and the famous analysis of variance (ANOVA) was established. In addition to establishing statistical methods, this paper also shows that some genetic characteristics with continuous variation can conform to Mendel's genetic law. Prior to this, the two were regarded as opposites by scientists. 19 18 After the war, Pearson originally invited him to enter the famous Gao Erdun laboratory at that time, but Fisher gave up the opportunity because he thought the competitive relationship between himself and Pearson was a career obstacle. It was not until 19 19 that Fisher chose to enter an agricultural laboratory called Rothamsted Experimental Station. This agricultural laboratory is located in Harpenden, Hertfordshire, England. Besides being a statistician, Fisher's director john russell also asked him to set up a statistical laboratory.
After that, Fisher began to conduct in-depth research on a large number of data collected over the years, and wrote the results into a series of papers entitled "Research on Crop Variation". His heyday also began at this time.
In the next few years, Fisher began to conceive new statistical methods, such as designing experiments. 1925, his first book was published, entitled "Statistical Methods for Researchers". 1935, the sequel of this book, Experimental Design, was published. These two books laid the foundation of experimental design methods and have been translated and reprinted many times.
In addition to the new statistical methods, Fisher also strengthened and revised the previous research on ANOVA, thus inventing the maximum likelihood estimation and developing statistical concepts such as sufficiency, auxiliary statistics, Fisher linear discriminant and Fisher information.