Bacterial drug resistance, also known as drug resistance, refers to the tolerance of bacteria to antibacterial drugs. Once drug resistance occurs, the chemotherapy effect of drugs will be significantly reduced. Drug resistance can be divided into acquired drug resistance and natural drug resistance according to its causes. Pathogens in nature, such as a certain strain of bacteria, will also produce natural drug resistance. When antibiotics are used for a long time, most sensitive strains are constantly killed, and drug-resistant strains reproduce to replace sensitive strains, thus increasing the drug resistance rate of bacteria. At present, it is believed that the latter model is the main reason for producing drug-resistant bacteria. In order to maintain the effectiveness of antibiotics, we should pay attention to their rational use.