Pharmacotoxicology: this product has broad-spectrum antibacterial effect in vitro, including aerobic gram-negative bacteria and gram-positive bacteria, anaerobic bacteria, rickettsia, spirochete and chlamydia. It has bactericidal effect on the following bacteria: Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis. Only the following bacteria can be inhibited: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridis, Group B hemolytic Streptococcus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis and other anaerobic bacteria. The following bacteria are usually resistant to chloramphenicol: Pseudomonas aeruginosa, Acinetobacter, Enterobacter, Serratia marcescens, Indole-positive Proteus, Methicillin-resistant Staphylococcus and Enterococcus. This product belongs to bacteriostatic agent. Chloramphenicol is fat-soluble, and its mechanism of action is that it diffuses into bacterial cells, reversibly binds to the 50S subunit of bacterial ribosomes, and hinders the growth of peptide chains (probably due to the inhibition of transpeptidase), thus inhibiting the formation of peptide chains and thus preventing the synthesis of protein.

Matters needing attention

1. Because there may be irreversible bone marrow suppression, repeated treatment with this product should be avoided.

2. Patients with liver and renal insufficiency should avoid using this product. If necessary, the blood concentration should be reduced and monitored so that the peak concentration (Cmax) is lower than 25mg/L and the trough concentration is lower than 5mg/L. If the blood concentration exceeds this range, the risk of bone marrow suppression may increase.

3. When taking this product orally, you should drink enough water and take it on an empty stomach, that is, before meals 1 hour or 2 hours after meals, in order to achieve effective blood concentration.

4. The peripheral blood picture should be checked regularly during the treatment, and reticulocyte count and bone marrow examination should be checked when necessary for long-term treatment, so as to find the dose-related reversible bone marrow suppression in time, but the whole blood picture examination can not predict the aplastic anemia that usually occurs after the treatment is completed.

5. Interference diagnosis: Chloramphenicol patients may have false positive reaction when urine sugar is determined by copper sulfate method. I found it in the drug information. I hope it will help you.