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The mechanism of bacterial drug resistance and how to prevent it were discussed.
The risk of abusing antibiotics is mainly to promote the enhancement of bacterial drug resistance. The data shows that more and more bacteria have developed drug resistance, and the drug resistance is constantly improving. In 1950s and 1960s, the dosage of penicillin was only 20,000 to 30,000 units, but now it needs hundreds of thousands and millions of units. Staphylococcus, Gram-positive bacilli, Mycobacterium tuberculosis and Shigella dysenteriae have ravaged human beings for a long time, which is the result of their increasing drug resistance. Because the evolution of bacteria will never stop, it is possible to develop resistance to any antibiotic. Li, director of Henan Province, introduced ciprofloxacin as an example at the press conference. In a short period of more than ten years, the drug resistance rate of Chinese patients reached 60%, while that of western developed countries was only 1%. The abuse of antibacterial drugs is making us pay a huge price. Adverse drug reactions and drug-induced diseases have greatly increased, and the energy of more and more bacteria against drugs has been increasing. For example, the resistance of Helicobacter pylori to quinolones has risen to 82%. "Bacteria are more and more resistant and antibiotics are more and more ineffective" has become a common problem in economically developed areas. According to Committee member Chen Zhonghua, Shanghai has become one of the regions with the most serious bacterial resistance in China, and the effective rate of some drugs in Shanghai has dropped to 20%. The problem is that drug-resistant bacteria can spread among people in different regions and countries. With the continuous improvement of medical conditions, new antibacterial drugs are constantly emerging. The extensive use of large doses of antibiotics and the extensive use of antibiotics in livestock feed additives make foods, dairy products and beverages rich in antibiotics, thus gradually forming an increasingly large population of antibiotic-resistant people. This leads to a vicious circle of using advanced antibiotics-more resistant-and then using more advanced antibiotics in clinic. Committee member Chen Zhonghua pointed out that the main reasons for the abuse of antibiotics are as follows: First, many doctors rarely rely on bacterial resistance test when giving antibiotics to patients, and choose different antibiotics for different bacterial infections, but often rely on personal experience to take one antibiotic and then use other antibiotics instead. Second, due to the fierce competition in the antibiotic drug market, some manufacturers often take improper measures to continuously increase the usage and dosage of antibiotics through publicity fees. Third, many patients have problems with their mentality of seeking medical treatment. I hope to use good medicine, often the more expensive medicine, the newer medicine, the better. I have always hoped that this medicine can cure the disease. These factors together make the production, sale, use and consumption of antibiotics want to use as much as possible. Together, they promote the abuse of antibiotics.