Preclinical research on drugs used for drug registration, including synthesis process, extraction method, physical and chemical properties and purity, dosage form selection, prescription screening, preparation process, inspection method, quality index, stability, pharmacology, toxicology, animal pharmacokinetics, etc. Traditional Chinese medicine preparation also includes the research on the source, processing and processing of the original medicinal materials; Biological products also include the origin, quality standards, preservation conditions, biological characteristics, genetic stability, immunological research and so on of original raw materials such as strains, cell lines and biological tissues.