In order to improve the curative effect and shorten the course of disease, several physical factors are often used comprehensively. Some at the same time, some successively, can play a synergistic or additive role. If the synthesis is improper, the effect may only be equivalent to one of them, or even weaken each other, resulting in antagonism. If hyperthermia is applied before or during the treatment, the effect of iontophoresis can be enhanced. Irradiating infrared rays before or at the same time as ultraviolet treatment can enhance the effect of ultraviolet rays. If infrared rays are irradiated after ultraviolet treatment, the effect will be reduced. Massage or other sports medical items after hyperthermia can enhance the effect of the latter. In a word, we should pay attention to the types, order, methods and correct cooperation of physical factors in comprehensive application.