Source of medicinal materials: whole herb of Rubia indica of Rosaceae. Harvest and storage: the whole grass is harvested in June-165438+1October.

Sexual taste

Sweet and sour; cold

Meridian tropism

Lung; Liver; Large intestine meridian

Functional indication

Clearing heat and cooling blood, detumescence and detoxification. It can be used for treating fever, epilepsy, cough, hematemesis, sore throat, dysentery, carbuncle, furuncle, snake bite and soup fire injury.

1 "Not recorded": fever in the main chest and abdomen.

② Tao Hongjing: The treatment is too cold and too hot.

3 "Dietotherapy Materia Medica": main chest and stomach heat; The older child was silent and poured juice into his mouth.

4 "Rihuazi Materia Medica": menstruation, sores and swelling, snake bite.

⑤ Compendium: Fire injury caused by applying soup.

⑥ Compendium of Materia Medica: Treating traumatic injuries, relieving swelling and pain, removing blood stasis and promoting regeneration, and soaking in wine to strengthen bones and muscles.

⑦ Textual Research on the Length of Plant Names and Figures: Tamping the Red Line.

⑧ Annals of Sichuan Traditional Chinese Medicine: Cooling blood and dredging channels. Treat convulsion, epilepsy, cold and heat, sore throat.

Pet-name ruby "Mindong Materia Medica": resolving phlegm and relieving cough, expelling wind and promoting blood circulation. Treat common cold, cough, asthma, toothache due to wind and fire, and sores on mouth and tongue.

dosage

Oral administration: decocted, 3-5 yuan (fresh 1-2 Liang); Or mash the juice. External use: tamping or grinding.

Additional prescription

1, cure internal heat and aphtha: Rubus natural juice, pound a barrel, fry five liters, and drink a little. (Essentials of typhoid fever)

2, cure summer heat, cold: 25-40 grams of dried raspberries, decocted with water, twice a day. (Fujian folk herbs)

3, cure hematemesis and hemoptysis: 100- 150 grams of fresh raspberry grass, smash a glass of juice, stew a little rock sugar. (Mindong Herbs)

4, treatment of sore throat: fresh raspberry grass stew oral and gargle. (Mindong Herbs)

5, treatment of children's aphtha: snake soaked grass (ground), dried alum powder, mixed, first wash the affected area with salt water, dried alum, and then sprinkle powder. (Guiyang folk herbs)

6, treatment of malaria, jaundice: fresh raspberry leaves mashed, with a large group of broad beans applied to the radial artery, cloth bandage. (Jiangxi folk herbs)

7, cure dysentery: 50 grams of fresh raspberry whole grass, decoction. (Jiangxi Handbook of Materia Medica)

8, cure snakehead boils, breast boils, back sores, boils: fresh raspberry grass, mashed, add honey to the affected area. For those who are not suppurated at the beginning, add 50g of dandelion, grind it into a pestle, wring a cup of juice, stew it with yellow wine 100g, and apply the residue to the affected area. (Mindong Herbs)

9. Cure snake pill: snake soaked grass in proper amount, realgar in five points and garlic in one piece. * * * Mash it, wrap it in cloth and put it outside. (Guiyang folk herbs)

10, treatment of impetigo: snake soaked grass stew to eat, and mashed for external application. (Guiyang folk herbs)

1 1, treatment of traumatic injury: fresh raspberry mashed, a little sweet wine, fried and applied externally. (Jiangxi herbs)

12, treatment of snake bites and poisonous insect bites: fresh raspberry grass, mashed and applied to the affected area. (Jiangxi folk herbs)

13, treatment of small area burn: fresh raspberry mashed and externally applied. If there is pus on the wound, add fresh plough grass; There is no pus, add a little borneol. (Jiangxi herbs)

14, treating cancer and furuncle: 15 ~ 50g, decocting in water. (Common Chinese herbal medicines in Shanghai)

15, treatment of scrofula: fresh Hedyotis diffusa 50 ~ 100g, washed and decocted. (Common Chinese herbal medicines in Shanghai)

pharmacological action

The anticancer water extracts of Duchesnea indica 1, 5mg/ml and 10mg/ml acted on human esophageal cancer Eca- 109 cell line cultured in vitro, which significantly inhibited its division index. 10mg/ml and 15mg/ml can reduce the density of Eca- 109 cells and make their structures blurred. After 48 hours of treatment, the colony formation of cells was obviously inhibited, and 15mg/ml could completely lose the reproductive ability of cells. 10mg/ml and 15mg/ml slightly inhibited the DNA synthesis (3H-TdR labeling) of Eca- 109 cells, indicating that the effect of Duchesnea indica on esophageal cancer cells may be mainly through inhibiting cell division and DNA synthesis. The polysaccharide fraction of S 100mg/kg and 200mg/kg showed obvious anti-tumor activity on S/ 180 sarcoma transplanted mice.

2. Enhance immune function. The liquid extract of wild raspberry (2g/ml) significantly improved the function of peritoneal macrophages in mice, showing that the cell body was obviously enlarged, and each cell body swallowed up as many as 7-8 chicken red blood cells, but there was no significant difference in digestive status between the two groups.

3. Fractions F-Ⅰ, F-Ⅱ and F-Ⅲ isolated from Indian berries were positive for the growth of Staphylococcus aureus and Shigella dysenteriae, weakly positive for Pseudomonas aeruginosa and negative for Salmonella paratyphi A.. Its F-V part is strongly positive for Staphylococcus aureus, Shigella dysenteriae and Pseudomonas aeruginosa, and its antibacterial activity exists in water-soluble part and water-insoluble part, but it is soluble in acetone. In addition, its concentration (above 0.5g/ml) has inhibitory effect on diphtheria (plastic foam infiltration-bacteriostatic ring method).

4. Influence on cardiovascular system. Its fluid extract has short-term antihypertensive effect on anesthetized dogs or rabbits, and it is dose-related. It can inhibit cardiac contraction (dogs) and heart rate (guinea pigs) and increase coronary flow.

5. Effect on smooth muscle: the fluid extract only increased the contraction amplitude of isolated intestine, but the tension did not change obviously, and inhibited the tension with the increase of dosage; It can stimulate isolated uterus of rabbits, guinea pigs and rats. The action intensity of 0.2ml/50ml (including 0.4g crude drug) was similar to that of 65,438+0 U pituitrin, but tolasulin (0.25mg/50ml) could not antagonize it. In vivo (rabbit) experiments showed that its fluid extract 2ml/kg was similar to pituitrin 1u/kg. It has no obvious effect on isolated trachea of guinea pigs.

6. Other effects: the ether extract of Duchesnea indica has androgen-like and histamine-like effects. It has no protective effect on erythrocyte membrane.

clinical application

1. diphtheria treatment: take fresh grass of three barks, mash it into mud, soak it in 2 times of cold boiled water for 4-6 hours, and filter to get 50% infusion. It is flavored with sugar and taken four times a day. 50ml for the first time under 3 years old, and 20-30 ml for each time thereafter; 80ml for the first time for 3-5 years old, and 40-50 ml for each time thereafter; 6- 10 years old, the first time 100ml, 60ml each time thereafter; 10 years old and above, the first time 150ml, and every time thereafter 100ml. 47 1 case after treatment; The cure rate is 85%.

2. Treatment of bacillary dysentery: Take the snake berry as a pill, 3 yuan each time, or make it into syrup, 20-40ml each time (halved in children), three times a day, and 5-7 days is a course of treatment. Cooperate with routine treatment of high fever, dehydration and abdominal pain. 50 cases were observed, 46 cases were cured, improved 1 case, and 3 cases were ineffective. Most of the cured cases developed fever within 1-2 days (the shortest time was 4 hours and the longest time was 6 days). Symptoms and signs disappear within 2-3 days (shortest 1 day, longest 6 days); After 3-5 days, the stool turned normal and the culture turned negative. The shortest medication time is 2 days and the longest is 1 1 day. During the treatment, a few patients experienced nausea, vomiting and epigastric discomfort, and no other adverse reactions were found.

3. Treatment of acute perforated appendicitis: Take 2-4 fresh Duchesnea indica (dried product 1-2) and 2-4 fresh white bone roots (sapiumsebiferumroxb). ) 5 yuan (dried 3 yuan), decocted in water twice. 65438+ 0-2 doses per day. Addition and subtraction: 3 yuan was added to cases of appendiceal abscess, and drugs for promoting qi and blood circulation were added to acute appendicitis complicated with localized or diffuse peritonitis, and the dosage of raspberries increased slightly (fresh products did not exceed 6 Liang per day and dried products did not exceed 4 Liang); If it is acute perforated appendicitis, it should be combined with Tongli attack medicine, such as fresh iron bar root (iris, iris) 5 yuan, ground into pulp with water, or taken at the end of kansui for 3 minutes each time. Stay in bed. Patients with localized peritonitis, especially patients with diffuse peritonitis, must take an oblique position. Others are given liquid, semi-liquid or short-term fasting as appropriate. Fasters should pay attention to the balance of water and electrolyte and correct acidosis. * * * 50 cases were treated, including appendix abscess 1 1 case, localized peritonitis 2 1 case and diffuse peritonitis1case. Results Cure (the conscious symptoms disappeared; The body temperature and white blood cells were normal in 38 cases, and the abdominal signs disappeared completely. 8 cases were cured (the symptoms of consciousness disappeared, the body temperature and white blood cells were normal, but there was slight deep tenderness or cord induration in the abdomen), and 4 cases were ineffective. The hospitalization factors ranged from 4 days to 43 days, with an average of 17 days. During the treatment, the body temperature, white blood cell count and classification returned to normal, and the shortest time for abdominal pain and tenderness to disappear was 1, 2, 3 and 5 days, with an average of 5, 8, 5 and 1 1 day. Both Duchesnea indica and Sapium sebiferum are toxic, but the dose of Duchesnea indica 1 is 4-6 liang (fresh) per day, and the root of Avicennia marina is 3-5 yuan per day. No toxic reaction was found. Some patients may have mild paroxysmal abdominal pain, which is due to the catharsis effect of Avicennia marina root, which enhances intestinal peristalsis and the pain disappears after defecation.

4, stable treatment of hepatitis A, patients with jaundice hepatitis A, take fresh grass every day, add appropriate amount of water, boil, and drink as herbal tea. Take it every day until it is cured, which can cure hepatitis A radically. Duchesnea indica is an excellent flower, which can be seen in spring and bear fruit in summer. The plant of Duchesnea indica is low, with dense branches and leaves, which has the characteristics of early turning green in spring, shade tolerance and long green period.

Every year from the beginning of April to 165438+ 10, the ground is covered with a thick layer of green, which can cover the ground well. Duchesnea indica blooms well in semi-shade, and the flower diameter can reach 65438±0cm. The flowering period is from April to 10, and yellow flowers are dotted on it, which breaks the dullness of green and gives people vitality. The fruit-bearing period can also last from May to June 10, showing the stunning rural red color in aggregate fruit.

As a perennial herb, it can reproduce itself thanks to years of turf establishment. In Beijing, the green period is more than 250 days, and the flowering and fruiting period can last from April to 165438+ 10, and the garden effect is outstanding. Because raspberries are not resistant to trampling, they can show good ornamental effect in closed green space.

Duchesnea indica is evergreen, fast growing, fresh in flowers, beautiful in fruit, short in plant, creeping and resistant to trampling. It is a rare and excellent ground cover plant. In Shang Hu Park in Changshu City, Jiangsu Province, patches of raspberries grow, forming a unique green landscape. In order to meet the requirements of biodiversity, many landscape projects began to design and apply Duchesnea indica.