Commonly known as amoxicillin
Chemical name (2S, 5R, 6r)-3,3-dimethyl -6-[(R)-(-)-2- amino -2-(4- hydroxyphenyl) acetamido ]-7- oxo -4- thio-1- azabicyclo [3.2.
Amoxicillin
English name amoxicillin
CAS number: 26787-78-0
constitutional formula
The molecular formula is c16h19n3o5s 3H2O.
Molecular weight 4 19.46
measure
Foreign name
Amoxicillin, amoxicillin, amoxicillin bustamoxicillin, amoxicillin, amoxicillin, amoxicillin, BRL-2333, bustamoxicillin, Clamoxil, Clamoxyl, Daxipen, Flemoxin, Larocin, Natamox, Oxetacillin.
Character; Role; letter
This product is white or white-like crystalline powder; It tastes slightly bitter. This product is slightly soluble in water and almost insoluble in ethanol. This product is acid-resistant, well absorbed by gastrointestinal tract and unaffected by food.
specific rotation
Accurately weigh this product, add water to dissolve and dilute it into a solution containing 1mg per 1ml, and the specific rotation is +290 degrees to +3 10 degrees according to the law.
Amoxicillin is a semi-synthetic broad-spectrum penicillin, and its antibacterial spectrum and activity are basically the same as those of ampicillin, but its acid resistance is stronger than that of ampicillin, and its bactericidal effect is better than that of ampicillin, but it cannot be used for the treatment of meningitis. The half-life is about 6 1.3 minutes.
Amoxicillin has strong bactericidal effect and strong ability to penetrate cell wall. After oral administration, lactam groups in drug molecules are hydrolyzed to form peptide bonds immediately, which quickly combine with transpeptidase in bacteria to inactivate it, cutting off the only way for bacteria to construct cell walls by synthesizing glycopeptides through transpeptidase, making bacterial cells quickly become spherical and rupture and dissolve, and finally bacteria rupture and die due to the continuous infiltration of water in cell walls. It has strong bacteriostatic and bactericidal effects on most pathogenic G+ bacteria and G- bacteria (including cocci and bacilli). Among them, it is moderately or slightly sensitive to hemolytic streptococcus, Brucella, Salmonella and Enterococcus. Hemodialysis can remove some drugs, peritoneal dialysis has no effect on removing this product.
Sensitive bacteria: A, B, C, F, G and unclassified streptococcus, Listeria monocytogenes, diphtheria, Neisseria meningitidis, Bordetella pertussis, Clostridium perfringens, Propionibacterium, Streptococcus suis, Streptococcus bovis, Salmonella, Eubacteria, Actinomyces, Leptospira and Treponema pallidum.
Unstable sensitive bacteria: pneumococcus, enterococcus faecalis, Escherichia coli, Proteus mirabilis, Shigella, Vibrio cholerae, Haemophilus influenzae, Neisseria gonorrhoeae and Clostridium which are sensitive or resistant to penicillin.
Drug-resistant bacteria: staphylococcus, catarrhalis, Klebsiella acidogenes, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas, Acinetobacter, Campylobacter, Wechsler's coccus, Mycoplasma, Rickettsia, Legionella, Bifidobacterium and Fragile Bacillus.