EGF (epidermal growth factor), also known as oligopeptide-1, is an active substance in human body.

There has been a lot of discussion about this matter.

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The advertising slogans commonly used by merchants are "the only beauty ingredient that won the Nobel Prize", "cutting-edge biotechnology" and "skin aging is caused by the decrease of EGF in the body".

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However, a considerable number of opponents with certain professional knowledge believe that EGF is pure deception and is carcinogenic or proliferative. They used some related papers to prove that EGFr (EGF receptor on human cells) is closely related to a variety of cancers, and pointed out that EGF is not a legal additive in skin care products, and there is no EGF in the ingredients approved by the state.

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User feedback is also polarized.

Some people think it is very effective, others think the effect is not amazing; Some people say that EGF has cured sensitive muscles, and some people say that they are allergic; Some people think that this ingredient is whitening and freckle-removing, and many people say it is pure whitening.

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What the hell is going on?

In order to facilitate children's shoes with tight time, let's draw a conclusion first:

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Wikipedia defines EGF like this.

Epidermal growth factor (EGF) is the earliest discovered growth factor, which plays an important role in regulating cell growth, proliferation and differentiation. Human epidermal growth factor protein has 53 amino acid residues and three disulfide bonds, with a mass of 6 thousand daltons.

Epidermal growth factor acts by binding to epidermal growth factor receptor (EGFR) on the cell surface. Its high affinity binding with epidermal growth factor receptor will stimulate the activity of tyrosine kinase inside the receptor, thus starting the cascade reaction of signal transduction system and causing various biochemical changes. The increase of intracellular calcium level increases glycolysis and protein synthesis, and the expression of some genes (including epidermal growth factor receptor) increases, which eventually leads to DNA synthesis and cell proliferation.

Combining relevant literature and our personal experience

This is the way we look at EGF.

For readers who have a strong demand for authority, please use EGF or human oligopeptide-1 as keywords to search for related papers. )

In the case of skin injuries and wounds

Recommended EGF repair effect

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Needless to say, the earliest battlefield of EGF was also used in the medical field to promote the healing of wounds and burns, and achieved good results in clinical verification. Major EGF brands have long known the people who promote this function, and we don't need to endorse it.

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Give a simple point:

No matter from our own experience (the experience of using EGF after Meiyangyang laser; Zhang Dashu's field case observation in medical beauty clinic), or from the scientific research results, EGF can help epidermal cells divide and regenerate faster and promote tissue repair in the case of obvious wounds and skin tissue damage.

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The Nobel Prize is a bit far-fetched.

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"The only Nobel Prize beauty ingredient" is probably the most publicized slogan. But this sentence is not accurate enough and even far-fetched. The accurate statement should be "beauty ingredients related to the Nobel Prize in Physiology or Medicine" because:

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It's a little tasteless for daily skin care.

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This part should be the most concerned part of most children's shoes. After all, it is not a part of the daily life of ordinary people to go to the medical beauty clinic from time to time and cut a knife and prick a needle in the face. What we are most concerned about is whether it has the advertised anti-aging effect when used on healthy skin.

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Although EGF does stimulate collagen, promote skin growth and repair collagen fibers, we have repeatedly said that its power can only be fully exerted when the skin is damaged and enters the skin through the wound on the skin surface. When the skin is not damaged, the cells will not react much when they receive EGF.

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Moreover, under the condition that the skin is healthy and complete enough, it is still inconclusive whether EGF for external use can be fully absorbed and utilized by the skin as advertised by the brand.

First of all, the cosmetic effect of using high-quality EGF alone on healthy skin is indeed the same as the experimental report of the scientific community, and it is generally not obvious. There are many opinions that the molecular weight is too large to be absorbed. However, there are some optimistic voices and some experiments on permeability, such as using pig skin to determine the absorption rate of EGF for external use. At the same time, the specific permeability of EGF is also related to skin condition.

Moreover, EGF, as a signal protein, is different from the commonly used cosmetic ingredients. How cells react after being absorbed by EGF-r of cells is not caused by a single factor, which determines the formula of the products you use, the activity, purity and storage conditions of EGF, and also affects the effect after you use the products.

Meiyangyang itself has used EGF products when its skin is healthy, but generally speaking, it has not had much obvious improvement effect on the skin.

The know-how behind EGF products

Since EGF is not effective on healthy skin, why do so many children's shoes feel very effective?

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Personally, I think it is possible: they bought a product called EGF, which is actually a compound of many ingredients. However, the most common components of some EGF products in China are various peptides, and the concentration of which is often particularly generous when added (for some unclear reasons, the cost is generally cheaper, such as replacing the original product with imitation peptides).

As for why do you want to do this? One reason is that EGF is famous and its publicity is strong. Another reason is that if EGF is self-produced, it can appear to have core technology (those peptides are copyrighted, so they are really not suitable for publicity as imitations).

Little is known about peptides

Because there are too many kinds of peptides, there are more than 40,000 kinds of peptides known to have applications, covering all walks of life, including hundreds in the field of light skin care. In addition, the naming of peptides in the industry is rather random, so children's shoes are very easy to be confused. For example, they always think that peptides are wrinkle-free, but there are many kinds of peptides.

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The general naming method of peptide is as follows: Take "acetyl hexapeptide -8" as an example, the front "acetyl" means that this peptide has been modified by acetyl, and there are similar modification methods such as biotin, palmitoyl and myristoyl; "Hexapeptide" refers to six kinds of amino acids (as for the specific amino acids, it depends on the molecular formula, there are always six permutations and combinations of 20); -8 means the first manufacturer who made or found this peptide, and thinks it is the eighth hexapeptide, or it just thinks the number 8 is auspicious (a joke), so this suffix is added to distinguish it from other acetyl modified hexapeptides.

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In fact, this suffix number of polypeptide classes often has to be changed because of naming conflicts. Sometimes a peptide has a wide range of uses, so it is directly named oligopeptide.

For example, EGF is called oligopeptide-1 (the first signal protein found). Generally, the following ten peptides are classified as peptides or small molecular peptides; More than 10 peptides and less than 50 peptides are classified as polypeptides; More than 50 peptides count as protein.

A new generation of epidermal growth factor

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Yes, in order to make EGF really shine in the beauty industry, raw material manufacturers are really not idle. EGF has a bionic peptide, which is a combination of fragments found in EGF- oligopeptide 24.

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The molecular weight of oligopeptide 24 is much smaller than EGF, so it is easy to be absorbed and stored, and the potential side effects may be much smaller. At present, it is considered that the efficacy in beauty is similar to EGF (which can be understood as a fragment of this part of the efficacy).

ReVive, an American luxury skin care brand that started with EGF and focused on the concept of biotechnology (the one previously recommended by Meiyangyang and recently sold to Shiseido for $654.38+0.2 billion), has already quietly replaced EGF originally added in all products with oligopeptide 24. EGF should be a traditional ingredient now, not a technology in the future.

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EGF is good, but don't drink too much.

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There is such a signal protein in human body, which is an important factor that causes seborrheic alopecia and leads to aging and apoptosis of various cells, and it has no other functions. In a word, it seems that all the bad things have been done, and everywhere I go, I look depressed.

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So should we get rid of this signal, protein?

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This ingredient is called DKK 1. Some researchers have actually done experiments to eliminate this protein-producing gene from mouse embryos. I want to see if such mice are not easy to age, and as a result, all embryos are deformed directly into stillbirths.

Because the function of DKK 1 in human body is to prevent the proliferation of developing organs and other tissues, it is an important signal protein to maintain the normal form of all parts of life.

Seborrheic alopecia is also caused by excessive DHT (dihydrotestosterone, an androgen, which is generally believed to cause hair loss), leading to excessive hair proliferation (you are not mistaken, it actually promotes hair growth). DKK 1 rushed up to suppress, and the result accidentally exceeded the balance.

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This example is to say that the system in the human body is a complex balanced system, and it is best to be extra cautious about the use and inhibition of such signal proteins. In contrast, EGF is a fairly safe signal protein, but besides cosmetic repair, it also has the ability to stimulate the activity of immune system and improve the activity of skin cells, which is also a double-edged sword.

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It is common that some children's shoes will have problems such as unstable skin condition and easy to grow small oil particles after long-term continuous use of high concentration EGF. Even if oligopeptide 24 is used too much, similar problems will occur when this effect is much smaller.

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In this regard, ReVive's approach is to instruct users who have purchased the ultimate essence with the largest oligopeptide 24 content (1500 USD 20ml) not to continue using one set after use, and to buy another set in a few months.

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? Ultimate suggestion

The same is true of our suggestions for children's shoes that like to use EGF:

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1, do not use high-concentration products for a long time, but the effect is better.

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2, the concentration of daily skin care should also be as conservative as possible.

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On the one hand, a considerable proportion of people are allergic to too much EGF or a small amount of protein impurities caused by EGF production; On the other hand, most active ingredients have the best concentration range obtained through practice, not the higher the concentration, the better, nor the faster the absorption. However, the concentration of active ingredients in general skin care products is generally too low, which will make children's shoes have the illusion that the higher the concentration, the faster the absorption and the better the effect.

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The myth of epidermal growth factor

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Most EGF manufacturers always say that Cohen won the Nobel Prize for this. However, the discoverer and main researcher of these growth factors, the legendary beauty Rita Levi Montalcini, who won the prize with Cohen, is always deliberately omitted. Why?

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Because she is so famous and frequent in Europe and America, and everyone knows that she is old:

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When I was young, it was like this:

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Do you think the propaganda team of EGF manufacturers is too fu-oriented?

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In fact, from the reports we found, she herself never used EGF to fight facial aging. Because since she found that licking wounds can accelerate healing, she and Cohen have studied the healing direction of EGF.

On the other hand, she has been using NGF (Nerve Cell Growth Factor) discovered by herself to keep her mind healthy, and to maintain high-intensity work every day before birth. Until 20 12 and 103, she was as quick-thinking, articulate and energetic as young people, but the anti-aging effect of NGF has not been clearly proved by large-scale clinical trials.