1., Ye Xiaoli, Wang Dezhen,,, Liu, Li. Safety evaluation of main alkaloids from coptis chinensis. Journal of ethnopharmacology, 2013.145: 303-310.

2. Ye Xiaoli, Cui, Li, Zheng and Zhu Chen. Adding berberine to cigarette filter can reduce the inhibitory effect of cigarette smoke on oral peroxidase activity. Toxicology and industrial health. 20 13.29(4):3 17.

3. Kai He and Xiao Liye? Li, Yuan Lujiang, Deng Yafei, Li Xiaoduo. Separation of two components in purple sweet potato by silica gel column and high-speed countercurrent chromatography. Journal of chromatography b.2012,881-882: 49 ~ 54.

4. The toxicity and hypoglycemic effect of the minor components of Coptis chinensis on HepG2 cells. Chen Hongying, Xiao Ye Li, Cui Xuelong, Kai He, Jin Yanan, Zhu Chen, Xue-Gang Li. Healthy growth. 20 12, vol. 83, Iss 1, pp. 67-73.

5. Yafeidengga, Ye Xiaoli, Li, Yuan Lujiang *, Jin Yalan, Jin Qing,. Saponin-rich components in Polygonatum odoratum. ) Druce, who has more potential hypoglycemic effect. Journal of ethnopharmacology,141(2012) 228–233.

6. Ye Xiaoli, Yi Jun, Li. Synthesis and bioavailability evaluation of 9-O- glycosyl berberine derivatives. Research on medical chemistry, 20 12. v 2 1(8): 164 1 ~ 1646。

7. Zhu Chen, Wang Mingxue, Zheng Jinfeng, Li. Synthesis and hypoglycemic activity of hesperidin derivatives. Bioorganic and bioengineering. Medicinal chemistry express. 2012, 22: 7194-7197.

8. Li, Ye Xiaoli, Yuan Lujiang, Li Xiaoduo, Deng Yafei. A method based on mitochondria, using 2', 7 '‐ dichloro? Oxidation of uorescin diacetate. Food Research International 48 (2012) 454–461.

9 Ye Xiaoli, Zhu Xiaokang,,,, Li. Synthesis and hypolipidemic ef Efficiency of berberine HMG-CoA reductase inhibitor. Research on Medical Chemistry, (2012) 21:1353–1362.

10., Ye Xiaoli, Li. Separation and purification of harpagoside and Angroside in Radix Scrophulariae by high-speed countercurrent chromatography C. September Science Journal. 20 12, 35, 2659–2664。

1 1. Teng, Xiao,, Xiao, Zuchen. Synthesis and antibacterial activity of 8- alkyl alanine derivatives. Drug design and research. It is found that 20 1 1, 8,464 ~ 468.

12., Li, Zhang Baoshun, Gang. Effect of 8- alkylserine homologues on erythrocyte membrane. Indian journal of experimental biology. 20 1 1.49(5):3 19~323.

132. Ye Xiaoli,,,, Li,, Wang Xiaohong. Effect of 8- alkyl berberine derivatives on reducing blood lipid in rabbits. Journal of medicinal plant research. 20 1 1, 5(8), 1390- 1394.

14., Ye Xiaoli, Zhu Chen, Yuan Lujiang, Li. Synthesis and antibacterial activity of 7- alkoxyhesperidin derivatives. Medical Chemistry Research, (2011) 20:1200–1205.

15. Xiao, Xiao, Xue. Synthesis and antibacterial activity of 8- alkyl coptisine derivatives. Asian journal of chemistry. 20 1 1, 23(9): 3849~3852

16. Li,,, Ye Xiaoli,,,, Deng Yafei, Jin Qing, Shi Qing, He Jingshu. Evaluation of hypoglycemic effect of some traditional Chinese medicines on STZ diabetic rats. Journal of ethnopharmacology. 137: 1 135~ 1 142。 20 1 1.

17. Synergistic effect and structure-activity relationship of 3- hydroxy -3- methylglutaryl coenzyme A reductase inhibitors in hawthorn. Agrich. Food chemistry. 20 10.58 (5):3 132–3 138.

18. Wei Haiping, Ye Xiaoling, Chen Zhizhong, Zhong Yujun, Li Chuanmin, Pu Shaocheng, Li Xiaoguang. Synthesis and pharmacokinetics of novel N- acyl cordycepin derivatives. European journal of medicinal chemistry, 2009, 44:665~669.

19. Li, Xiao, Zhu Chen, Qing, Xiao, Niu Xiaohua. Synthesis and antibacterial activity of 3- octyloxy -8- alkyl jatrorrhizine derivatives. Asian Journal of Natural Products Research, 2009, 1 1(4):365~370.

20. He Zhenliang, Ye Xiaoling, Mou, Chen, Synthesis and anti-injury activity of capsaicin derivatives. European Journal of Medicinal Chemistry, April 2009: 3345 ~ 3349.

2 1. Zhu Chen,, and Xiao. 9-O- butyl-berberine bromide. Journal of Crystals E, 2009, E65, o 1370.

22. Xiao Li, Li Xu, Xue Gang and Li Bo? , Zhu Chenbo, Zhang Baoshun, Yuan Lujiang, Xing Chenbo, Zhang Huajin, Wen Changga, Su Na Shengliang. Antibacterial mechanism of houttuynia cordata homologues against Bacillus subtilis. Colloid and surface A: physical chemistry and engineering. 350 (2009):130–135.

23. Wang Lijun, Li, Gang *, Yu Gang, Gang, Tian, Zhang Hua. Synthesis and antibacterial activity of 3- alkoxy jatrorrhizine derivatives. Plant Medicine, 2008, 74:290~292.

24. Ye Xiaoli, Li, Yuan Lujiang, Ge, Zhou. Interaction between houttuynia cordata homologues and cell membranes of Gram-positive and Gram-negative bacteria. Colloids and Surfaces A: Physical, chemical and engineering aspects. 2007,30 1:4 12~4 18.

25. Yuan Lujiang, Ye Xiaoli, Li. Effects of sodium sulfite series of octadecyl acetal with different double bond numbers on its immunity and surface activity. Asian Journal of Natural Products Research, September 2007 (1): 49 ~ 58.

26. Yong Yang, Ye Xiaoli, Li,,. Synthesis and antibacterial activity of long-chain 8- alkyl berberine derivatives. Plant medicine, 2007, 73:602~604.

27. Ye Xiaoli, Li,. Interaction between houttuynia cordata homologues and rabbit erythrocyte membrane in vitro. Colloids and Surfaces A: Physical, chemical and engineering aspects. 2006,279:2 18~224.

28. Ye Xiaoli, Li, Yuan Lujiang, He Hongmei. Relationship between antibacterial and immune activities of houttuynia cordata homologues and their surface activities. Research on Natural Products in Asia, 2006,8 (4): 327 ~ 334

29. Ye Xiaoli, Li,. Effect of surface activity on antibacterial activity of sodium octadecyl acetal series. Colloids and Surfaces A: Physical, chemical and engineering aspects. 2005, 268:85~89。

30. Wang Bingjun, Zhang Zhiguo, Li Xiguo, Wang Yongjun, He Chunyan, Zhang Jiansheng, Chen Shuyou, "Cloning and Analysis of a Soybean Disease Resistance Gene Homologous Sequence", Acta Botanica, 2003,45 (7): 864 ~ 870.

3 1. Ye Xiaoli, Li, Shu Changbing, Chen,. (2000) Effects of surfactants on invertase and SOD activities of soybean leaves in vitro and in vivo. Colloid and surface, 175:249~255.

32. Ye Xiaoli, Li, Chen, (2000) Effect of SFE on invertase activity of soybean leaves in vitro and in vivo. Journal of Plant Physiology, 26(5):446~452.

33. Steel, steel, steel, steel and steel. (1996) Surface activity and solubilization of anionic and cationic surfactants. Colloids and surfaces,11:161~166.

34. Port Li Xue, Liu Famin. Phase separation of (1995) aqueous solution and surface activity of oxyethylene cationic anionic surfactant. Colloids and surfaces, 96: 1 13.

35. Zhao Guo, Xue Ligang, (199 1) Solubilization of n-octanol and n-octane by mixed aqueous solution of cationic and anionic surfactants. J. colloid and chemical company. Interf。 Sci， 144: 185。

36. Chen Hongying, Xue-Gang Li, Ye Xiaoli, Jin Yanan, Huang Jing and Wu Jinfeng. Separation of choline from coptis chinensis and its effect on glucose metabolism of berberine in HepG2 cells. Journal of traditional chinese medicine, China, 2012,37 (12): 26 ~ 31.

37. Ding Yangping; Ye Xiaoli; Zhou Jie; Rossai; Practice dreaming; Xue-Gang Li. Progress in synthesis and physiological activities of berberine derivatives. Organic chemistry, 20 12.32: 667 ~ 685.

38. Jin Qing, Bai Xiaohua, Deng Yafei, Xue-Gang Li and Yuan Lujiang. Study on the effective parts and components of Radix Aucklandiae for lowering blood sugar. Chinese herbal medicine, 2012,43 (7):1371.

Li Qiong, Ye Xiaoli, Zeng Hong, Xin Chen, Xue-Gang Li. Study on extraction technology and hypoglycemic activity of trichosanthin. Chinese herbal medicine, 2012,35 (3): 475.

40. Kai He, Xue-Gang Li, Chen Hongying, Ye Xiaoli, Deng Yafei, Xin Chen and Sun Shengliang. Determination of alkaloid partition coefficient of coptis chinensis by TLC fluorescence method. Analytical chemistry, 20 1 1, 39 (4): 572 ~ 575.

4 1. Zhang Baoshun, Ye Xiaoli, Zhu Chen, Yao Bo, Tan Ping, Xue-Gang Li. Synthesis and anti-inflammatory effect of methyl hesperidin -7- alkyl ether homologues. Journal of Pharmacy, 20 1 1, 46 (7): 811~ 817.

42. Jiang, Tang Lin and Ye Xiaoli. Synthesis of 8- alkyl coptisine homologues and its hypoglycemic effect in vitro. Chinese herbal medicine. 20 1 1,42(4):640~643。

, Sun Fengqing, Li, Wang Haoju, Feng,,. Prevention and treatment of angora rabbit fever emergency with traditional Chinese medicine. China Veterinary Journal. 20 1 1,47(5):75。

44. Ye Xiaoli,,,,, Gao Ying, Zhao Zhongqi, Huang, and Yi Jun. Metabolic transformation and distribution of coptis alkaloids in rats. Journal of traditional chinese medicine, China, 2010,35 (15): 2017 ~ 2020.

45. Huang, Ye Xiaoli, Lan Ping, Gao Ying, Zhu Jiaying, Ping Li,. Study on active components in hawthorn and their synergistic effect. China Journal of Traditional Chinese Medicine, 20 10/0,35 (18): 2428 ~ 2400103667.

46. Zhu Xiaokang; Ye Xiaoli; Yuan Lvjiang; Zhu Jiaying; Ding Yangping; Xue-Gang Li. Synthesis and antibacterial activity of 6- alkoxyrhein under microwave irradiation. Organic chemistry, 20 10/0,30 (9):1335 ~1341.

47. Ding Yangping, Ye Xiaoli, Zhu Jiaying, Zhu Xiaokang, Xue-Gang Li. Synthesis of 8- alkyl-13- bromoberberine hydrochloride and its effect on the proliferation of human hepatocellular carcinoma cells. Chinese herbal medicine, 20 10/0,41(11):1765 ~1770.

48. Ping Li, Wang Xiaohong, Feng Ping, Xue-Gang Li and He Chen. Clinical observation on 30 cases of type 2 diabetes mellitus with yin deficiency and heat excess treated by pingpingshu. New Chinese medicine, 20 10/0,42 (9): 31~ 33.

49. Yu Gang, Cao Xiaogang, Ye Xiaoli, Xue-Gang Li, Zhu Chen, Yuan Lujiang and Wang Lijun. Determination of the activity of 3- hydroxy -3- methylglutaryl coenzyme A reductase inhibitor by HPLC. Analytical chemistry, 2009, V37 (1): 87 ~ 90.

50. Xu Li, Xue-Gang Li, Zhu Chen, Zhang Fei and Ye Xiaoli. Determination of the effect of houttuynia cordata Thunb on fatty acid synthase activity in duck liver by HPLC. Analytical Chemistry, 2009,37 (5): 729 ~ 732.

5 1. Li Yamei, Ye Xiaoli, Li, Chu Haofeng, Liu Guoyin, Effects of excipients on absorption and pharmacokinetics of total alkaloids from Coptis chinensis in mice. China Journal of Traditional Chinese Medicine, 2009,34 (3): 344 ~ 348.

52. Wei Huiping, Ye Xiaoli, Zhang Huaying, Xue-Gang Li, Zhong Yingjun. Study on efficient production of cordycepin by solid-state fermentation of Cordyceps militaris. Journal of traditional chinese medicine, China. 2008,33( 19):2 159~2 162。

53. Li, Ye Xiaoli,,, Determination of Houttuynia cordata homologues in animal tissues by HPLC. Analytical Chemistry, 2007,35 (2): 297 ~ 300.

Yong Yang, Ye Xiaoli, Zheng Jing, Zhang Baoshun, Xue-Gang Li. Synthesis and activity of 8- alkyl berberine hydrochloride. Organic Chemistry, 2007,27 (11):1438 ~1440.

55. Zhang, person. (1993) Effect of guanidine hydrochloride and urea on hydrophobic energy of hydrophobic chain in solution. Journal of chemistry, 5 1 (8): 869 ~ 873.

56 Xue-Gang Li, Zou Chenglu. (1993) Effect of hexylbiguanide hydrochloride on creatine kinase activity and rubber construction. Journal of biophysics, 9 (1): 1 ~ 5.

Patent technology

1, "The method of comprehensive utilization of cystine mother liquor wastewater to produce single amino acid and eliminate pollution". Patent number: ZL0 1 132740.5.

2. Coptis chinensis flower or/and leaf tea. Inventors: Xue-Gang Li, Yuan Lvjiang, Ye Xiaoli. China technology invention patent, patent number: ZL200510020601.x.

3. Coptis chinensis pesticide synergist. Inventor: Xue-Gang Li; Wu Guangquan; Ye Xiaoli; He Hongmei. China technology invention patent, patent number: ZL 2005 1 00206005.

4,8-octyl berberine hydrochloride, synthesis method and application. Inventor: Ye Xiaoli; Xue-Gang Li. China technology invention patent, patent number: ZL2006 10095288.0.

5. Long-chain alkyl berberine salt derivatives, synthesis methods and applications. Inventor: Ye Xiaoli; Xue-Gang Li. China technology invention patent, patent number: ZL2007 10078505. X

6,4-alkoxycoumarin fatty acid ester, synthesis method and application. Inventor: Ye Xiaoli; Xue-Gang Li; Yuan Lvjiang. China technology invention patent, patent number: 2008 10070223X.

7,8-alkyl galanthamine salt, preparation method and application thereof. Inventor: Ye Xiaoli; Xue-Gang Li. China technology invention patent, patent number: ZL2009 10 103606.7.

8. Extraction method of coptisine. Inventor: Xue-Gang Li; Ye Xiaoli; Yuan Lvjiang. China technology invention patent, patent number: ZL2009101916207.

9. Extraction technology of total alkaloids from Rhizoma Coptidis. Inventor: Ye Xiaoli; Xue-Gang Li; Yuan Lvjiang. China technology invention patent, patent number: ZL2008 1006967 1.8.

10, a compound Chinese herbal medicine preparation for preventing and treating rabbit fever emergency. Inventor: Xue-Gang Li; Von. China technology invention patent, patent number: ZL200910103145.3.

1 1, a Chinese herbal medicine compound preparation for preventing and treating swine winter dysentery. Inventor: Xue-Gang Li; Von. China technology invention patent, patent number: ZL200910103144.9.

12, antihypertensive drug 3- alkoxy-mangiferin, synthesis and application. Inventors: Ye Xiaoli, Xue-Gang Li. China technology invention patent, patent number: ZL200910104184.5.

13. An extraction method for coproducing coptis alkaloids with coptis root as raw material. Inventor: Xue-Gang Li; Ye Xiaoli. China technology invention patent, patent number: ZL2008 10233362. X

14, a compound preparation of traditional Chinese medicine for treating diabetes. Inventor: Xie. China technology invention patent, patent number: 2009 10 103527.6.

15. A method for extracting acidic components such as ferulic acid and chlorogenic acid from Rhizoma Coptidis. Inventor: Xue-Gang Li; Ye Xiaoli. China technology invention patent, patent number: ZL201010514629.x.

16, a compound preparation of Rhizoma Coptidis for treating diabetes with damp-heat and spleen stagnation. Inventor: Xue-Gang Li; Ye Xiaoli. China technology invention patent, patent number: ZL20 10 10547697.6.

Application of 17 and N- alkanoyl cordycepin in preparing medicines for treating tumor diseases. Inventor: Ye Xiaoli; Xue-Gang Li. China technology invention patent, patent number: ZL2009 10 104006.2.

18, a compound of coptis alkaloids and ferulic acid with hypoglycemic effect. Inventor: Xue-Gang Li; Ye Xiaoli. China technology invention patent, patent number: ZL201010514620.9.

19, multifunctional compound Chinese herbal toothpaste. Inventors: Li Qiong, Ye Xiaoli, Xue-Gang Li, Yuan Lujiang. China technology invention patent, patent number: 201110085036.0.

20. A Chinese medicinal compound preparation for preventing and treating diabetic nephropathy. Inventors: Xue-Gang Li, Yi Jun, Ye Xiaoli. China technology invention patent, patent number: 20110258401.3.

2 1, 3- alkoxy -6- carboxyl rhein or its pharmaceutically acceptable salt, and its preparation method and application. Inventor: Xue-Gang Li; Zhu Xiaokang China technology invention patent, patent number: 2009 10 104466.5.

22. A method for improving antibacterial activity of leaf extract of FAGACEAE. Inventors: Yuan Lvjiang, Xue-Gang Li, Jin Qing, Deng Yafei. China technology invention patentNo.: 201110031074.8.

23. A Chinese medicinal composition for treating diabetes and its preparation. Inventors: Xue-Gang Li and Ye Xiaoli. China technology invention patent, application number: 2011kloc-0/044253.4.

24. Preparation method of pueraria flavone extract and its products. Inventors: Xue-Gang Li, Yuan Lvjiang, Ye Xiaoli. China technology invention patent, patent number: 20110458717.7.

25. A jade Ge Fen with slimming and beautifying effects and its preparation method. Inventors: Xue-Gang Li and Ye Xiaoli. China technology invention patent, patent number: 201210035015.2.

26.9-O- glycoside-berberine salt, its preparation method and application. Inventors: Yuan Lvjiang, Ye Xiaoli, Xue-Gang Li. China technology invention patent, patent number: 20 10 10589543.3.