He has successively undertaken 22 projects including National Natural Science Foundation, Fok Ying Tung Education Fund, International Science Fund, provincial and ministerial scientific research projects and horizontal cooperation projects, published 205 papers, published 8 monographs, granted 8 patents and won 2 provincial and ministerial scientific research achievement awards. There are 6 professors, 6 associate professors, 6 lecturers, 4 doctoral supervisors and 8 master supervisors.
Professor: Ouyang Wuqing Li Xinping Yang Zhao Huiying
Associate Professor: Li Zhang Miaotao Qing Suzhu Luo Xu Yongping
Lecturer: Zhou Congrihua, Zhao Xiaomin
The experimenters: Qiao Hailian, Artemisia, Chrysanthemum, Kangzhike, Zhang, Animal Anatomy and Histoembryology. They took the lead in the research on the neuroanatomy of livestock and poultry in China, published the first monograph on neuroanatomy, and put forward a new theory of extracentral reflex arc, which formed distinct features in the brain nuclear localization and innervation of internal organs of livestock and poultry, the expression characteristics of neuropeptide in hypothalamus-pituitary-gonadal axis and immune factors, and the relationship between neuropeptide and hormones and immune factors.
Monoclonal antibodies against Marek's disease tumor-associated surface antigen (MATSA) were prepared by animal pathology, which laid a foundation for the related research of Marek's disease and the development of anti-tumor drugs based on monoclonal antibodies. Artificial synthesis of immunogen against swainsonine induces animals to produce antibodies with strong specificity and high titer. Through hybridoma cell technology, hybridoma cells secreting specific antibodies against swainsonine were obtained, and monoclonal antibodies against swainsonine were prepared, which explored a new way to prevent and treat livestock locoweed poisoning. The signal transduction pathway of apoptosis induced by natural products, the construction of a new baculovirus surface display system platform and the development of common animal virus subunit vaccines are being carried out.
Research and Development of New Veterinary Drugs Since 2006, a variety of liquid nanomaterials, polymer nanomaterials and metal nanomaterials have been developed, and 35 national invention patents have been applied for in the research of nano veterinary drugs, and 7 have been authorized, which has certain advantages and characteristics in the research of new veterinary drugs in China and has achieved a number of achievements with independent intellectual property rights. At present, the veterinary basic research platform consists of animal anatomy, animal histology and embryology, veterinary pharmacology, animal pathology laboratory and slicing room.
preventive veterinary medicine
This degree was authorized in 1984, and the first-level discipline of veterinary medicine was awarded a doctorate in 2003. Preventive veterinary medicine began to recruit doctoral students in 2004. Over the years, it has formed three research directions: molecular etiology and immunology, animal disease prevention and veterinary hygiene. Since 2000, 143 graduates have been trained, and 109 students are studying for master's degrees. Since 2004, 1 1 doctors have been trained, and 23 doctors are studying for doctoral degrees.
He is in charge of 3 national natural science foundation projects, 3 sub-projects supported by the National 863 Program, 4 major scientific research projects in Shaanxi Province, and more than 0 natural science foundation and key projects in Shaanxi Province/kloc-0. Won the first prize 1 item, 5 second prizes and 6 third prizes for scientific and technological progress in Shaanxi province. Won the special prize of 1 Shaanxi teaching achievement; Editor-in-chief: Animal Food Hygiene (3rd edition, 4th edition), Veterinary Hygiene (2nd edition, 1 edition) and Animal Food Hygiene Experimental Guide, 2 1 century course materials, edited 20 books. Animal food hygiene is an excellent course in Shaanxi Province.
Academic team
Teach Zhang Yanming three subjects, Yang Zengqi, Chen Dekun and Zhang Deli.
Associate Professor Xu Xingang Lin Yang Gao Yunying
Lecturer Xing Fushan Guo Kangkang Liu Fangning Qiu Yan Fenqi Dandan
Experimenter Party Ruyi (Senior Experimenter) Zhang Yaoxiang Ning Pengbo
Research characteristics
Establishment of Immortal Cell Line and Study on Pathogenic Mechanism A porcine vascular endothelial cell line was established, which has been passed to122nd generation and used to study the pathogenic mechanism of classical swine fever virus. The epithelial cell line of porcine small intestine was established, which has been passed down to 90 generations and used to study the pathogenic mechanism of porcine diarrhea.
Study on New Vaccine for Livestock and Poultry A genetically engineered cell vaccine for classical swine fever was successfully developed by using the established porcine vascular endothelial cell line. The fowlpox virus live vector vaccine and adenovirus live vector vaccine expressing E0 and E2 genes of classical swine fever virus were successfully developed. Cell vaccine of infectious bursal disease in chicken and engineering vaccine of avian Escherichia coli fusion strain with different outer membrane protein types were successfully developed.
Diagnosis and differential diagnosis methods of major diseases of livestock and poultry The RT-PCR differential diagnosis methods for distinguishing virulent classical swine fever infection from attenuated rabbit vaccine immunization, for distinguishing virulent, virulent and attenuated strains of infectious bursal disease virus, and for distinguishing virulent and attenuated strains of Newcastle disease were established. A PCR diagnostic method for bovine tuberculosis, mycoplasma hyopneumoniae and rabbit brucellosis was established. The diagnostic technical standard of goat caseous lymphadenitis (NY/T 908—2004) was established.
Scientific research conditions
There are three biosafety laboratories (BSL-3) and scientific research platforms (including P2 cell culture laboratory and molecular biology laboratory) for the prevention and control of livestock and poultry diseases and the safety of livestock products.
Clinical veterinary medicine
There are four doctoral and master's degree authorization points in developmental biology, cell biology, neurobiology and physiology. In 2000 and 2004, the discipline began to recruit master's and doctoral students. Up to 2008, 6 graduate students have been trained, including 77 masters, 23 doctors and 7 masters1person.
This discipline * * * presided over the completion of 1 national "973" project, 2 "863" projects, 3 national key projects, 5 national natural funds and 8 provincial and ministerial key projects. He won 3 provincial and ministerial scientific and technological progress awards, published 36 SCI papers, applied for 56 national invention patents and established 23 projects. Editor-in-chief or participated in the compilation of seven national textbooks, including Animal Physiology, Cell Biology, Neuroanatomy of Livestock and Poultry, and Animal Physiology Experiment, and published monographs 10.
Academic team:
This discipline has formed a developmental biology academic team with Professor Zhang Yong as academic leader, a cell biology and physiology academic team with Professor Ouyang Wuqing as academic leader, and a neurobiology research team with Professor Fan Guangli as academic leader. Composition of each team:
Developmental biology major:
Instructors: Zhang Yong and Zhao Huiying.
Associate Professor: Quan, Qing Suzhu, Zheng Yuemao, Xu Yongping Lei.
Lecturer: Song Hua
Cell biology and physiology:
Instructors: Ouyang Wuqing and Li Xinping.
Associate Professor: Zhang Miaotao
Lecturer: Zhang Wenlong Cong Rihua
Neurobiology major:
Teaching: Zhao Huiying
Associate Professor: Xu Yongping, Chen Shulin.
Lecturer: Zhang Qi
Research features:
Developmental biology major:
Developmental biology in our hospital has formed two distinctive research directions: (1) animal cloning and animal transgenic technology research; (2) Study on the mechanism of animal morphogenesis. Great progress has been made in the mechanism of mammalian germ cells, the molecular regulation mechanism of early embryo implantation, the polarity of early embryo cleavage, the abnormal development of animal cloned embryos and epigenetics, and it has formed a national second-class key discipline of biology featuring the study of cattle and sheep cloning mechanism and animal morphogenesis mechanism.
Cell biology major:
The specialty of cell biology in our college has formed an advantage specialty featuring nanotechnology research. Since 2006, we have developed a variety of liquid nanomaterials, polymer nanomaterials and metal nanomaterials, applied for 50 national invention patents and granted 17, which is in a leading position in domestic nanotechnology research.
Neurobiological research:
Taking pigs, sheep and chickens as representative animals of livestock and poultry, a series of studies on the brain structure of hypothalamus-pituitary-gonad reproductive axis and the neural-immune-endocrine network in different physiological periods were carried out, and the research direction of neural-immune-endocrine network on reproductive regulation was formed. Taking livestock and poultry as experimental animal models, the distribution and changes of neuropeptides, hormones and immune cytokines in nerve, endocrine and immune organs at different development stages of major animal diseases were studied, and the research direction of "neurobiological mechanism of animal diseases" was formed. The new research results will provide a new theoretical basis for livestock breeding and disease prevention and control.
Scientific research conditions:
(1) Establish animal cloning and transgenic technology platform and developmental biology research technology platform.
(2) Two national first-class innovation platforms, animal physiology and cell biology, were established. Among them, Animal Physiology Laboratory and Cell Biology Laboratory have been awarded the titles of National Experimental Teaching Demonstration Center (Animal Science Experimental Teaching Center), Animal Science Experimental Teaching Demonstration Center of Shaanxi University, Demonstration Experimental Zone for Talent Cultivation of Shaanxi Province, Animal Science Experimental Teaching Center of Northwest A&F University and Animal Science Experimental Teaching Center.