Caroline Bettozzi, 1
Caroline Bertozzi, female, born in June 1966 10 in the United States, is a professor at Stanford University.
2. Carl Barry Sharples
194/kloc-0 was born in Philadelphia, Pennsylvania, USA on April 28th, 2000. He is a chemist, a foreign academician of China Academy of Sciences, an academician of American Academy of Arts, an academician of American National Academy of Sciences, a Nobel Prize winner in chemistry (twice), Professor W.M.Keck of Scripps Institute, and distinguished professor of Shanghai Institute of Organic Chemistry of Chinese Academy of Sciences.
3. Morten Meldahl
Morten Meldahl, male, born in 1954, Ph.D. in data transmission unit, professor at Copenhagen University.
Reasons for winning:
In 2022, the Nobel Prize in Chemistry was awarded to American scientists Caroline Bettozzi, Carl Barry Sharples and Danish scientist Morten Meldahl for their contributions to the development of click chemistry and bioorthogonal chemistry.
The concept of click chemistry comes from an article published by sharpless in the early 20th century. Sharpless believes that the formation of chemical bonds between carbon atoms is a major obstacle to chemical synthesis. Carbon atoms from different molecules often lack chemical motivation for bonding, and the process of artificial activation reaction will lead to many unnecessary by-products.
He proposed a more controllable path, that is, using nitrogen atoms or oxygen atoms as "bridges" to splice small molecules with complete carbon skeletons. This method is called click chemistry.
Shortly thereafter, Meldahl and sharpless independently reported the "copper-catalyzed cycloaddition of azidoalkynes" reaction, which was called the "crown jewel" of click chemistry. When Meldahl catalyzed the reaction of alkynes with acyl halides with copper ions, it was found that alkynes reacted with intermediate azides to form cyclic triazoles.
Meldahl saw the value of the reaction between azide and alkyne. In 2002, he said in an academic article that this reaction can be used to combine many different molecules. In the same year, sharpless also published a paper on the copper-catalyzed reaction between azide and alkyne, and described it as a "perfect" click reaction.