With amino group, it is the only alkaline animal fiber with positive charge in nature, so it has very unique physiological and biochemical functions, and is known as the "sixth life factor of human body" abroad, which is pure natural, non-radioactive and pollution-free.
As early as 400 years ago, the application of crab shell was recorded in Compendium of Materia Medica, which is the earliest application record of chitin. 18 1 1 year, after French scholar Brakno first isolated chitin from crustacean shells, medical circles, universities and nutritional food research institutions in the United States and Europe successively put into research. Japan took the lead in putting chitin, chitosan and chitosan oligosaccharide on the market as functional foods after clinical practice, and became the only functional food allowed by the Japanese Ministry of Health and Welfare (equivalent to the Ministry of Health of China). At the same time, the Japanese government has also invested heavily in development and marketing. From 65438 to 0997, the research and development of chitosan oligosaccharide was included in the Ninth Five-Year Plan of the State Science and Technology Commission, belonging to the 863 Plan.
Chitooligosaccharides and cardiovascular diseases
There are many kinds of cardiovascular and cerebrovascular diseases, such as coronary heart disease, cerebral hemorrhage and cerebral thrombosis. The research causes are all caused by cardiovascular and cerebrovascular sclerosis. The hardened vascular wall thickens and hardens, the elasticity decreases, and the lumen shrinks, resulting in slow blood flow and insufficient blood supply to tissues and organs. The therapeutic mechanism of chitosan oligosaccharide is to activate vascular cells, restore vascular elasticity and repair damaged vascular wall. In addition, it can activate red blood cells, which are responsible for transporting oxygen and nutrients to various organs of the body and bringing back carbon dioxide. If red blood cells lose their activity, it means that red blood cells are connected in series to form balls, which directly affects their oxygen carrying capacity. Chitosan oligosaccharide can change the pressure difference between inside and outside red blood cells, relieve the aggregation of red blood cells and improve the ability of oxygen transfer and exchange, thus effectively preventing and treating coronary heart disease, angina pectoris and myocardial infarction. Chitosan oligosaccharide can promote the secretion of bile acids, thereby decomposing excess cholesterol, and fundamentally treating and preventing cardiovascular and cerebrovascular diseases.
Chitosan oligosaccharide and diabetes mellitus
Diabetes is an endocrine and metabolic disease with a certain genetic tendency. If it is not treated in time or not well controlled, it will lead to serious complications such as cardiovascular, eye, kidney and nervous system. As dietary fiber, chitosan oligosaccharide can slow down the absorption of sugar by diabetics, activate the function of islet cells, promote insulin secretion (insulin activity increases by 30% when the PH value increases by 0. 1), improve its hypoglycemic ability, adjust the pH value of body fluids, and promote the sensitivity of body cells to insulin, thus preventing and treating diabetes.
Prevention and treatment of type 2 diabetes with chitosan oligosaccharide. Type II diabetes, also known as adult onset diabetes, usually occurs after 35-40 years old, accounting for more than 90% of diabetic patients. The ability of patients with type II diabetes to produce insulin has not been completely lost. Some patients even produce too much insulin, but the effect of insulin is greatly reduced, which is what we often call "insulin resistance". Therefore, the insulin in the patient's body is only relatively lacking, and some oral drugs can be used to stimulate insulin secretion in the body to achieve therapeutic effects.
Insulin resistance is one of the main causes of type II diabetes. The decrease of GLUT-4 expression, transport efficiency and activity can lead to the formation of insulin resistance.
Chitosan oligosaccharide can improve the gene expression level of glucose transport carrier GLUT-4, promote glucose transport to insulin-sensitive tissues for intracellular utilization, improve the sensitivity of tissues to insulin and improve insulin resistance, thus playing a preventive and therapeutic role in type II diabetes.
Chitooligosaccharides and cancer
Chitosan oligosaccharide is a dietary fiber with positive charge, which will form dense inclusion bodies on the surface of cancer cells and play the following roles: 1. Stop the nutrient supply of cancer cells, reduce their division and limit the conditions for cancer cells to divide; Second, reduce the acidic waste produced by cancer cell metabolism, on the other hand, improve the acidic environment around cancer cells and create environmental conditions in which cancer cells are difficult to survive, divide and transfer. Third, reduce various enzymes (lipolytic enzyme, hydrolytic enzyme, protease, etc. ) is released from cancer cells to the surrounding area, and the catalytic effect of various enzymes on surrounding healthy cells is reduced. In addition, immune cells with anti-cancer function of chitosan oligosaccharide have the strongest attack in weak alkaline state, while the surrounding of cancer cells is generally acidic. Chitooligosaccharides can neutralize acidic substances around tumors, activate immune cells with anticancer effect in human body, and play a role in cooperating with chemotherapy, improving symptoms, relieving pain and prolonging life.
Healthy people also produce more than 654.38+00000 cancer cells every day. Chitosan oligosaccharide is a kind of polysaccharide with alkaline groups, which can shift the PH value of blood to alkaline, thus activating lymphocytes and making them in the best active state, improving the function of LAK cells by about 3 times and the activity of NK cells by about 4.5 times. These immune cells are the key factors to prevent cancer.
Blood vessels are channels for cancer cells to metastasize, and cancer cells can only metastasize to other organs of the body if they adhere to molecules on the surface of blood vessels under acidic conditions. Chitooligosaccharides have stronger adhesion than cancer cells (experiments prove that chitooligosaccharides can directly act on the cell surface). In addition, chitooligosaccharides can push the body to alkaline, thus preventing cancer cells from combining with molecules and inhibiting the metastasis of cancer cells.
Chitooligosaccharides and blood sugar
Chitosan oligosaccharide can reduce blood sugar, enhance load glucose tolerance, improve the function of islet cells, and has a tendency to increase blood insulin, which is related to the fact that chitosan oligosaccharide can act on insulin receptor and enhance the sensitivity of insulin receptor, thus controlling the increase of blood sugar. At the same time, some studies have found that there is an Escherichia coli in the intestine, which can produce insulin-like receptors and block insulin receptors, so that real insulin can not play a hypoglycemic role, while chitosan oligosaccharide can promote the proliferation of beneficial bacteria such as intestinal Bifidobacterium, produce biological antagonism, inhibit this Escherichia coli and control blood sugar.
Qingdao Maidier biological chitosan oligosaccharide is quite good.