According to foreign media reports, recently, Professor King Cao, vice president of China-Japan Friendship Hospital, and other experts published the clinical study of lopinavir/ritonavir in the treatment of severe adult coronavirus pneumonia-19 in the New England Journal of Medicine, which proved that the anti-AIDS drug HIV protease inhibitor lopinavir/ritonavir had no obvious effect on COVID-19.
The clinical trial of lopinavir/ritonavir conducted by this group showed that 94 critically ill patients in COVID-19 received lopinavir/ritonavir treatment, and 65,438+000 critically ill patients received standard treatment, with an average age of 58 years.
Among them, 5 1 patient had serious adverse reactions: 9 cases in lopinavir/ritonavir group/kloc-0, and 32 cases in standard treatment group. There were 4 cases of serious gastrointestinal adverse reactions in the lopinavir/ritonavir group, while there were no adverse reactions in the standard treatment group.
In terms of mortality, after 28 days, the mortality rate in the lopinavir/ritonavir group was 65,438+09.2%, and that in the standard treatment group was 25.0%. From the time of clinical improvement, the median time of clinical improvement in the Lopinavir/Ritonavir group was 65438 05 days, and that in the standard treatment group was 65438 06 days.
The article also said that for patients with severe COVID-19's disease, lopinavir/ritonavir could not significantly accelerate clinical improvement, reduce mortality or reduce the viral load in the throat.
Dr. Lindsay Baden and Dr. Eric Rubin, editors-in-chief of the New England Journal of Medicine, also said: This research attempt is not afraid of difficulties, but unfortunately the result is disappointing.
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