The earliest study on radiation resistance of ganoderma lucidum
In the late 1970s, in order to observe the effect of Ganoderma lucidum fruiting body extract on mice's resistance to harsh environment (conditions), we designed a series of experiments such as anti-hypoxia, anti-cold, anti-high temperature, anti-fatigue and anti-radiation.
At that time, we didn't have cobalt -60 radiation equipment, so we always used school buses to escort dozens of experimental mice to the radiation laboratory of China Academy of Agricultural Sciences, which was a luxury in that era when all people rode bicycles.
In the experiment, each mouse was fixed in a special glass cylinder, and a cobalt -60 source was placed equidistantly around it, and irradiated with cobalt -60γ-rays for 15 minutes. The dose rate of Co -60 is 60.4R/min (about 529. 1mGy/min), and the total dose is 906R (about 7.9Gy). After irradiation, the mice were transported back to the laboratory for feeding, and the mortality rate was observed for 30 days.
The results showed that after 20 days of intragastric administration of Ganoderma lucidum extract (equivalent to 10g/kg fruiting body) and 30 days of irradiation, the mortality rate of mice in control group was 44.4%, while the mortality rate of mice in control group was 70.4% after intragastric administration of normal saline. After Co -60γ -ray irradiation, mice were injected with the same dose of ganoderma lucidum solution. There was no significant difference in mortality between the two groups 30 days after irradiation, but the average survival time of animals was significantly prolonged. This discovery was published in the Chinese and English versions of Science Bulletin of 1980. It is the first research paper on the radiation resistance of Ganoderma lucidum, which has attracted the attention of academic circles.
Science can stand repetition.
The results of scientific experiments should stand up to repetition. After more than ten years, some laboratory studies have obtained similar results:
(1) Ganoderma lucidum extract has a certain protective effect on the damage caused by X-ray irradiation in mice, which can slightly improve the survival rate of 30 days after irradiation and promote the recovery of body weight and blood indexes of mice after irradiation.
(2) preventive use of ganoderma lucidum extract 4Gy? γ -ray irradiation has obvious protective effect on the damage caused by mice, and can obviously improve the leukopenia and immune function reduction caused by irradiation.
(3) intragastric administration of ganoderma lucidum spore powder in mice can reduce cobalt -60? γ -ray induced leukopenia and improved the survival rate of mice.
(4) Before X-ray irradiation, feeding mice with Ganoderma lucidum mycelium water extract (MAK) can protect mice from X-ray irradiation damage, significantly prolong the survival time of mice and improve the survival rate of small intestinal gland cells.
These studies have proved that the fruiting body, mycelium and spore powder of Ganoderma lucidum have the function of anti-radiation damage.
The clinical effect is the most scientific.
At present, the anti-radiation effect of Ganoderma lucidum has been applied in clinic. One is to reduce the damage of tumor radiotherapy, such as leukopenia, gastrointestinal reaction (such as vomiting) and decreased immune function, which I mentioned many times in my column. The second is to treat leukopenia.
Leukopenia means that the white blood cells in peripheral blood are lower than 3.5 *10 9/l/l, and the reason is not completely clear. It may be related to the influence of physical and chemical pollution in the environment and the disorder of genetic or immune mechanism of the body. The former includes the influence of various radiation factors.
From the change of clinical white blood cell normal value standard, we can also see the deterioration of human living environment. During my clinical period of 1960, the lower limit of the normal value of the total white blood cell count was 6.0x 10 9/L 09/L. With the passage of time, this value dropped to 5.0x 10 9/L, and today it is 3.5x 10 9/L, which can be said to be deteriorating.
Some preliminary clinical observations show that Ganoderma lucidum is effective for leukopenia caused by various reasons. For example, 52 cases of leukopenia were treated with Ganoderma lucidum capsule (containing ethanol extract of Ganoderma lucidum mycelium and its solid culture medium), and the total number of white blood cells before treatment was less than 4000 /mm? . Take 4 capsules of Ganoderma lucidum orally each time, three times a day, *** 10? 14 days. The average white blood cell count of 52 patients increased after treatment 1028/mm? The total effective rate was 84.6%.
The total number of white blood cells increased by 2000 /mm compared with that before taking the medicine? 1 1 case, accounting for 2 1. 15%, and the total number of white blood cells increased 1000 compared with before taking the medicine. 2000/mm？ 12 cases, accounting for 23.1%; The total number of white blood cells increased by 500 compared with that before taking the medicine? 1000/mm？ 2 1 case (improvement), accounting for 40.4%; 8 cases were ineffective, accounting for 15.4%. After treatment, the total number of white blood cells increased to 4000? 6700/mm？ In 30 cases, the curative effect of the subjects who took medicine for 20 days was better than that of the subjects who took medicine for 10 days.
Another example: 60 cases of leukopenia were treated with Ganoderma lucidum mycelium tablets (the mycelium used included solid culture medium components). The total number of white blood cells in this group was 4500/mm before treatment. Below, there are 9 cases with definite etiology (3 cases with long-term exposure to gasoline and diesel, 6 cases with chronic diseases) and 5 cases with unknown causes. After taking Ganoderma lucidum mycelium tablets (0.4g each time, 3 tablets each time, twice a day) 10? After 30 days, the average white blood cell count increased 1428/mm? The total effective rate was 865,438 0.7% and the recovery rate was 75%. Conscious symptoms such as dizziness, fatigue and insomnia have also improved to varying degrees.
The above results show that Ganoderma lucidum does have a certain protective effect on radiation damage, and people who use Ganoderma lucidum for health care for a long time have stronger resistance to nuclear radiation than ordinary people. Of course, this hypothesis needs further research to prove.
From: Lin Zhibin's Lingzhi Zongtan