Studies on chemical constituents and biological activities of natural plants in Guizhou, especially genuine medicinal materials and Miao medicines: standardization of traditional Chinese medicines, natural medicines and their preparations, characteristic spectra and spectrum-effect relationship of traditional Chinese medicines and their preparations; Study on preclinical development of new traditional Chinese medicine and Guizhou Miao medicine. Resume: 1998- 1999, with the support of the National Scholarship Committee, I went to the University of Toronto in Canada as a visiting scholar. In the past 20 years, he has been engaged in quality standards of traditional Chinese medicine, research and development of new traditional Chinese medicine, fingerprint research of traditional Chinese medicine and its preparations, drug metabolism research and extraction, separation, purification and structural identification of natural products; At the same time, he has taught graduate and undergraduate courses such as introduction to modern chemical research methods, analytical chemistry, modern instrumental analysis, spectral analysis, humanistic reflection on modern science and technology, and selected lectures on the history of drug development. , trained 1 doctoral students, 19 master students and 5 graduate students. He presided over the National Natural Science Foundation Project 1, other provincial and ministerial projects 10, and cooperated with enterprises. Some achievements have been made in the research of fingerprint, quality standard and natural products of traditional Chinese medicine. The research results provide good technical support for Guizhou Shenqi Group, Guizhou Xinbang Pharmaceutical, Guizhou Hongyu Pharmaceutical and other well-known pharmaceutical enterprises, provide theoretical basis for the in-depth development and utilization of their fist products, improve the internal quality control level of traditional Chinese medicine preparations, improve their scientific and technological content and economic added value, and provide reference for the material basis research of Guizhou endemic Miao medicines. In recent years, more than 50 papers have been published in academic journals at home and abroad, and "Chemical research and application of effective components of 24 kinds of traditional Chinese medicines and ethnic medicines in Guizhou" won the second prize of scientific and technological progress in Guizhou Province in 2004.