From 65438 to 0929, Liu Zhixun served as secretary of the Hubei Provincial Committee of the Communist Party of China and was soon transferred to the Central Military Commission.

1April, 930, Liu Zhixun was sent to Honghu Revolutionary Base, and served as the director of the Political Department of the Second Red Army Corps, a member of the former enemy committee of the Corps, and a political commissar of the Sixth Red Army Corps. 1931March, the Second Red Army Corps was renamed the Red Army Corps, and Liu Zhixun was appointed as the director of the political department and a member of the front committee of the Red Army Corps. At that time, he and He Long, a young soldier, and Duan Dechang, a younger and better commander of the Red Army, led the Red Army to repel the enemy's repeated sieges and consolidated and developed the revolutionary base areas in western Hunan and Hubei.

Liu Zhixun is also a civil and military generalist. At that time, in order to motivate the soldiers, he wrote a "Red Army Running Song" with the rhyme of the epigraph "Jiangchengzi".