Main research direction: 1. Molecular epidemiology and molecular pathogenesis of pathogenic microorganisms II. Study on gene function of pathogenic organisms. Diagnostic methods of pathogenic organisms and research and development of insect-derived drugs: research focuses on cryptosporidium and human cytomegalovirus. By means of bioinformatics, molecular biology and epidemiology, the virulence factors with pathogenic function, immunocompetent molecules with immunomodulatory function to host, diagnostic antigen molecules with diagnostic value and insect-derived molecules with pharmacological function were studied, so as to analyze their pathogenic mechanism and immunomodulatory mechanism, establish new immunodiagnosis and gene diagnosis methods, and develop insect-derived drugs. Academic papers:, Zhou,, etc. Experimental study on diagnosis of cryptosporidium parvum infection by nested PCR. Journal of tropical medicine. 2008; 8 (11):1109-11,1/65438. Clonorchis sinensis China Journal of Zoonosis 2006, 8:720-723, Jing, et al. Cloning and expression of a new proteasome β 1 gene from Clonorchis sinensis. China public health 2006,22: 1 470-1472 scientific research project1. Regulation of Cryptosporidium parvum CypA on CD4+T cell differentiation and function and its mechanism II. Virulence factors of cryptosporidium and its molecular mechanism of invasion into host cells were discovered by Guangdong Medical Research Fund 3. Study on regional structure and protein expression profile of overlapping sequence 4 of human cytomegalovirus UL48A-49-49A supported by China Postdoctoral Science Foundation. The cloning, function and application in immunodiagnosis of LIP gene of cryptosporidium were reviewed. 5. The construction of human cryptosporidium cDNA library and the cloning and functional research of new genes have been completed by Jinan University. Research project 1. Study on the regional structure and function of overlapping sequence of human cytomegalovirus UL48A-49-49A in 2007-2009 by National Natural Science Foundation of China: 2. Anti-prostate tumor research co-mediated by Guangdong Natural Science Foundation Psap/Rhox5 in 2008-2010; 3. Functional Genome Research of Model Organisms (Human Parasites) Supported by Guangdong Natural Science Foundation: 4. Comprehensive Prevention and Control Research in liver fluke disease from 2002 to 2005; 5. Screening of Clonorchis sinensis-specific secreted antigens by mimic protein chip technology, a key project of Guangdong Natural Science Foundation in 2004-2006. Awards 1. The second prize of China Medical Science and Technology Award (2008202) Establishment of Clonorchis sinensis gene and functional research (winner of the seventh prize) 20082. Study on the establishment and function of gene expression profile of Clonorchis sinensis (winner of the sixth prize), second prize in the third undergraduate teaching competition of Jinan University, and first prize in the undergraduate teaching competition of Medical College of Jinan University in 2008. Ming patent: 1. Clonorchis sinensis class I aldehyde dehydrogenase and its coding nucleic acid and application (fifth patentee) 2. Clonorchis sinensis proteasome subunit C3 and its coding nucleic acid and application (sixth patentee).