The earlier menarche, the later menopause.

Rumors:

The core of female dysmenorrhea is ovarian follicular function. Follicles periodically produce estrogen and progesterone during their growth and development, and then act on the endometrium. If you are not pregnant, the endometrium will periodically bleed and form menstruation.

Follicles are non-renewable, so use one less. The period with the largest number of follicles in a woman's life is at birth, about one million. With the increase of age, follicles gradually die out, and there are basically no follicles in menopause, or only hundreds or thousands of silent follicles. With the development of menstrual cycle, only about 400 ~ 500 follicles can be used for pregnancy, which can be said to be very small compared with the number of follicles that die.

Theoretically speaking, the earlier menarche, the more mature follicles, the faster the death rate and the earlier the menopause age when the number of follicles remains unchanged. Historically, it is a fact that the age of menarche is getting earlier and earlier, but the age of menopause has hardly changed since ancient times.

The ancient book "Su Wen? There is a cloud in the ancient naive theory: "The woman is seven years old, full of kidney qi and has longer teeth;" On the 27 th, the sunflower arrived, letting the pulse pass, too rushing the pulse, the month is in the present, so there is a son; The 77 network is weak, the pulse is too weak, the sunflower is exhausted, and the tunnel is impassable, so the shape difference is childless. " On February 27th, menarche was equivalent to 14 years old, and on July 7th, menopause was equivalent to 49 years old.

In the real world, advancing menarche age does not delay menopause age. The survey in 20 10 shows that the age of menarche of women in China is gradually advanced, and the average age of urban women is 12.27 years old; The survey of natural menopause age shows that the average age of Beijing women is 49.32 years old, and that of Shanghai women is 50.6 3.7 years old, which is about 49 years old.

Many scholars at home and abroad have studied whether menarche age affects the natural menopause age, and the conclusion is basically not, or the earlier menarche age, the earlier menopause age will be. 20 18 Authoritative magazine Human Reproduction published a paper. Through the investigation of 336,788 Norwegian women, it is found that the menopause age of women with menarche age (≥ 16 years) is later than that of women with menarche age (13 years) 1 year.

These are the main factors that really affect menopause: 1. Genetic factors, the mother's menopause age is very important, and some chromosome abnormalities are easy to menopause early; 2. Medical factors, such as ovarian surgery, radiotherapy and chemotherapy, etc. 3. Autoimmune factors, some immune diseases will also accelerate follicular consumption; 4. Environmental factors, personal bad habits, etc. For example, radiation and chemicals in the living and working environment often stay up late and do not exercise. Of course, in more cases, the influencing factors of menopausal age cannot be clear.

To sum up, in the real world, the age of menarche is advanced, but the age of menopause is not delayed.

Rumor expert: Zou Fudan University Affiliated Obstetrics and Gynecology Hospital Chief Physician, Deputy Director of Gynecological Endocrinology and Reproductive Medicine Department.

Evaluation expert: Tan Xianjie, chief physician, professor and doctoral supervisor of Peking Union Medical College Hospital of China Academy of Medical Sciences.

References:

Xie Xing, Kong Beihua, Duan Tao. Obstetrics and gynecology The ninth edition. Beijing: People's Health Publishing House, 20 18.

[2] Collaboration Group of Adolescent Development Investigation of Endocrine Genetics and Metabolism Group of Pediatrics Branch of Chinese Medical Association. Investigation on the development of secondary sexual characteristics and menarche age of girls in nine cities of China. China Journal of Endocrinology and Metabolism, 20 10/0,26 (8): 669-675.

Mas, Ma, Ma and so on. Analysis of menopausal symptoms of perimenopausal women in Beijing. Journal of Reproductive Medicine, 2008(05): 13- 18.

[4] Chen Hua, Feng, Shu Huimin, et al. Investigation on menopausal age and menstrual period of women in Pudong New Area of Shanghai and analysis of its influencing factors. Chinese Journal of Obstetrics and Gynecology, 20 10/0,45 (6): 415-419.

[5]BjellandEK, HofvindS, BybergL, etal. Relationship between age and natural menopause: A population survey of 336,788 Norwegian women. Human reproduction, 2018,33 (6):1149-1157.