Low chlorine alkalosis or low chlorine alkalosis, thiazide drugs, especially hydrochlorothiazide, often increase chloride excretion significantly. In addition, hyponatremia is not uncommon, which will lead to central nervous system symptoms and aggravate kidney damage. The decrease of blood volume and renal blood flow caused by dehydration can also cause the decrease of glomerular filtration rate. The common clinical reactions of the above water and electrolyte disorders include dry mouth, polydipsia, muscle spasm, nausea, vomiting and extreme fatigue. (2) hyperglycemia. The drug can reduce glucose tolerance and increase blood sugar, which may be related to the inhibition of insulin release. (3) Hyperuricemia. Interference with renal tubular excretion of uric acid, a few can induce gout attack. Because there is usually no joint pain, hyperuricemia is easily overlooked. (4) Allergic reactions, such as rash and urticaria, are rare. (5) Leukopenia or deficiency and thrombocytopenic purpura are also rare. (6) Others, such as cholecystitis, pancreatitis, sexual hypofunction, light sensitivity, color vision disorder, etc. , are rare.