Definition 1:
The ideal biological bone graft material needs good biocompatibility. The so-called biocompatibility refers to the reaction of the body to the implant after the biomaterial is implanted in the body.
From: the application of bioactive glass in the treatment of alveolar bone defect ... Chinese Journal of Dental Materials and Instruments, Xin Wang, 2000! 2500 12, yangpishan! 2500 12, qi! 2500 12
Definition 2:
Biocompatibility refers to the ability of materials to cause appropriate host reactions and material reactions in specific practical applications. The interaction between matter and life is mainly manifested in two aspects. One is material reaction, that is, the action of biological organism on materials, including corrosion, degradation, wear, performance degradation and even destruction of materials by biological environment.
Source: Structure and properties of biological hard tissue and coating implant materials ... Journal of Leshan Teachers College, 2005, Deng Chi, Shi Shousheng, Li Jian, Song Jiuhua, Xia Liewen.
Abstract: biological tissues and organs are complex fine structures formed in the long-term evolution of the body. As an artificial implant that replaces the function of tissues and organs, it will undoubtedly be very different from biological tissues and organs in structure. In this paper, the basic structure and properties of bio-hard tissue bones and teeth are compared with the corresponding artificial coated implants. The results show that when biological hard tissue is regarded as composite material, its tissue structure is similar to that of coated implant, and coated implant can complete the basic functions of hard tissue. Coated composite material is a promising biomedical material to replace hard tissue.
Definition 3:
Generally speaking, biocompatibility refers to the interaction between blood and foreign substances such as dialysis membrane or adsorbent. When the reaction is mild and the patient can tolerate it, this material is called biocompatibility. At present, due to the application of some biocompatible membranes, such as blood-like membranes, the acute hemodynamic instability caused by dialysis membranes has been significantly reduced.
Source: Changes of peripheral blood cell composition in patients with HA hemoperfusion ... china journal of modern medicine, 2005, Zhu Wenping, Zeng Bin, Zheng Huifeng.
Objective To investigate the effect of hydroxyapatite hemoperfusion on blood cell composition. Methods Three groups of patients with acute poisoning, chronic renal failure and chronic renal failure were treated with hemoperfusion, hemodialysis+hemoperfusion and hemodialysis respectively, and the changes of blood cell composition before and after treatment were compared. Results There were no significant changes in erythrocyte, leukocyte, platelet, HGB and HCT in hemoperfusion group before and after treatment (P> Hemodialysis+Hemoperfusion group and Hemodialysis group increased significantly after treatment (P < 0.05), but there was no significant difference between the latter two groups. Conclusion HA hemoperfusion device has no obvious effect on peripheral red blood cells, white blood cells, platelets and other tangible components.
Definition 4:
Biocompatibility means that all materials, equipment, samples or systems do not cause obvious clinical reactions to the host, that is, "thrombosis, no toxicity, no allergic or inflammatory reactions, no destruction of blood cells" and little complement activation.
Excerpt: Comparison and application of dialysis efficiency of various hemodialyzers in modern medical instruments, 2000, Chen, Pan.
Abstract: By detecting and comparing the clearance rates of water, creatinine, urea nitrogen, phosphorus, vitamin B_( 12) and β_2 microglobulin in 60 hemodialysis patients, it is found that the large-flow dialyzer can remove water, phosphorus, vitamin B _ (12) and β _ 2 microglobulin.
Definition 5:
Biocompatibility refers to the degree of immune system's response and tolerance to foreign bodies. This experiment shows that the animal body has good biocompatibility with the stent made of stainless steel wire, and there is no inflammatory and necrotic change in the blood vessel wall after stent implantation.
Source: Experimental Study of Endovascular Stent. China Journal of Clinical Medical Imaging 1998 Cui Jinguo, Feng Yanjiao, Sun.
Experimental Study on Endovascular Stent (050082) Cui Jinguo Pathology Department, Cheng and Sun Electron Microscope Room of Radiology Department of Bethune International Peace Hospital With the extensive development of interventional radiology in China, the application of endovascular stent is increasing gradually. This new technique can not only treat vascular diseases with poor curative effect of percutaneous transluminal angioplasty (PTA), but also treat complications of PTA. ...
Definition 6:
Toxicity and biocompatibility of materials are another issue that must be considered when evaluating new materials. Biocompatibility refers to the complex biological, physical and chemical reactions produced by the interaction between materials and human body, and the tolerance of human body to these reactions.
From: Biocompatibility of Nano-hydroxyapatite Artificial Bone china journal of modern medicine 2005 Jiang Hanping, Wang Daping, Ruan Jianming, Zhu Weimin.
Objective To evaluate the biocompatibility of a new nano-hydroxyapatite artificial bone, and to provide evidence for its clinical application in the field of bone defect repair. Methods Acute toxicity test, pyrogen test, intradermal test, muscle implantation test and bone implantation test were carried out respectively. Results Nano-hydroxyapatite artificial bone material was nontoxic and pyrogen-free, and gradually degraded after being implanted into rabbit muscle. Conclusion The nano hydroxyapatite artificial bone material has good biocompatibility.
Definition 7:
Biocompatibility means that osteoblasts grown on materials (active and non-1a), PLA and glass have shorter morphology and smaller cell spreading (see figures 1b and 1c).
From: Study on Compatibility of Novel Modified Polylactic Acid with Osteoblasts Journal of Biomedical Engineering 2005 Su Aihua, Luo Yanfeng, Wu Keda.
Abstract: The cell compatibility between osteoblasts and a new biodegradable material, ethylenediamine modified polylactic acid (EMPLA), was discussed. Osteoblasts were cultured on PLA, EMPLA and glass (control group), and the growth of cells was observed by cell morphology and cell proliferation method under phase contrast microscope. At 1, 2, 4 and 6 days, the growth curve was drawn by MTT method. The experimental results show that the osteoblasts in EMPLA group have better morphology and faster proliferation rate than those in PLA group and control group, indicating that EMPLA has better cell compatibility than PLA and has a wide application prospect in biomedicine, especially in tissue engineering.
Definition 8:
Biocompatibility refers to a property that biological tissues can react with non-biological materials. (2) Medicinal polymer materials There are three main aspects of medicinal use of polymer compounds. One is as a carrier for controlled drug release.
From: Biomedical Materials and Artificial Organs, New Materials Industry, 2000.
Biomedical materials are an important branch of materials science. Its application in medicine has provided a rich material foundation for the development of medicine, pharmacy and biology, and in turn, the progress of these disciplines has continuously promoted the further development of biomedical materials. Biomedical materials have become one of the four pillars of biomedical engineering because of their great contribution to exploring the mysteries of human life and ensuring human health and longevity. The ultimate goal of biomedical materials research is to use them to replace and repair human organs and tissues and realize their physiological functions. Artificial organ (artificial)
Definition 9:
The so-called biocompatibility refers to the specific or non-specific reaction between blood and biomaterials. Dialysis membrane is an important cause of biocompatibility during hemodialysis, and the research on biocompatibility between cytokines and membrane has been paid more and more attention.
From: Biocompatibility of IL- 1 and TNF with Dialysis Membrane Journal of Kidney Disease and Dialysis Kidney Transplantation 1994 Mao, Zhu.
Biocompatibility of IL- 1 and TNF with dialysis membrane. The capillary and capillary dialysis membrane is one of the most important components in hemodialysis, and the ideal membrane material should have good biocompatibility. The so-called biocompatibility refers to the specific or non-specific reaction between blood and biomaterials. In the process of HD, dialysis membrane is an important cause of biological incompatibility, which is different from cells ...
Definition 10:
Biocompatibility refers to the ability of materials to continuously complete the specified functions in vivo or in vitro within a specified time. Contrary to the obvious, in most cases, the selection criteria and failure reasons of materials generally belong to the consideration of biocompatibility.
From: Material Selection of Medical Plastics Application of Engineering Plastics 200 1 Key, Gu Yi
Abstract: The principle of material selection for medical plastics is expounded, the requirements for material properties of medical plastics products and the types and characteristics of applicable materials are introduced, the development status of medical plastics is summarized, and its development trend is predicted.