A 54-year-old male worker who keeps drinking bottles every day not only leads to chronic pancreatitis, alcoholic liver disease and long-term diarrhea, but also leads to calcium oxalate crystal nephropathy, which eventually requires long-term renal dialysis. Gao Mingcong, director of the Department of Nephrology, Hong Kong Hospital, said that there are many oxalates in normal vegetables and fruits, and only 65,438+00% of them are absorbed into the blood by the intestine and then excreted by the kidneys. When the absorption of oxalate in the intestine increases and the normal excretion of oxalate in the kidney decreases, oxalate may be deposited in the kidney, causing permanent damage to the kidney.
Excessive accumulation of calcium oxalate crystals leads to renal interstitial fibrosis
Director Gao Mingcong said that patients themselves know that the source of the disease is alcohol addiction, but they just can't quit drinking addiction. Recently, acute renal failure (uremia) broke out and began to receive hemodialysis treatment (kidney dialysis). Two months later, because the renal function did not recover and the kidney did not atrophy, renal biopsy showed that there were many calcium oxalate crystals accumulated in renal tubules and interstitium, and chronic renal tubular atrophy had formed renal interstitial fibrosis.
Normal vegetables and fruits contain a lot of oxalate. If you ingest 65,438+000 grams per day, about 65,438+00 grams will be absorbed by the intestine, and the body will produce 24 grams per day from the liver. Therefore, it will absorb and produce 34 grams of oxalic acid every day, which is generally excreted by the kidney to achieve the balance of oxalic acid in the body. If intestinal fat malabsorption is combined with dehydration, it will increase intestinal oxalate absorption and decrease renal excretion. Too much oxalate that cannot be discharged will accumulate in renal tubules and cause inflammation, leading to renal tubular atrophy and renal interstitial fibrosis.
Chronic pancreatitis, surgical resection of small intestine, etc. It may increase the absorption of oxalic acid in the intestine.
The diseases that usually cause the intestinal absorption of oxalate to increase include chronic pancreatitis, small intestinal resection, intestinal resection, intestinal fat malabsorption and so on. Reducing the risk of oxalate excretion from the kidney includes long-term diarrhea and insufficient water intake.
Director Gao Mingcong emphasized that a healthy pancreas, a healthy liver and a healthy intestine are very important. Once calcium oxalate crystal nephropathy is found, we should reduce the intake of oxalate and use pancreatin to help digestion, prevent diarrhea and reduce dehydration. However, the above cases should be lifelong regrets caused by long-term alcoholism, which also shows that excessive drinking will not only damage the liver, but also lead to problems in the pancreas, intestines and even kidneys. (Article authorized to provide/Youhuo Health Network)