A unique three-dimensional cell culture model for studying the interaction between cells-double-layer cell ball culture model; In the study of early diabetic nephropathy, it has been confirmed that the interaction between endothelial cells and mesangial cells can promote the increase of oxidative stress level of mesangial cells, significantly up-regulate the expression of fibroblasts, and promote the proliferation of mesangial cells and the secretion of extracellular matrix (fibronectin and collagen IV). Tea polyphenols can effectively interfere with this interaction between endothelial cells and mesangial cells; It is found that there is abnormal interaction between colon cancer cells and interstitial cells, which plays an important role in the occurrence and evolution of tumors, providing a new perspective for exploring the pathogenesis of diabetic nephropathy and colon cancer and a new idea for finding new therapeutic targets.

He has undertaken 7 national and provincial scientific research projects, including 2 national natural science foundation projects, participated in 4 international conferences (2 conference reports), and published more than 0 papers in domestic core journals. Lecturer in undergraduate and postgraduate courses such as pathology, molecular pathology, modern pathology, pathological progress and clinical pathology. Train 20 graduate students (18 graduates). Deputy editor-in-chief and editor-in-chief of 2 national planning textbooks, translated 1.