At present, there are more than 20 kinds of collagen found in the study, among which type I and type III collagen are the main types in our facial skin. Early functional protein mainly came from animal tissue processing technology. This kind of collagen mainly from fish skin is mostly produced by type I collagen, while type III collagen is unique to mammals. Therefore, some scientists extracted from pig, cattle and other biological tissues, and selected some animals similar to human genome as extraction objects to avoid possible rejection and supplement urgently needed type III collagen. However, this situation can not be completely avoided, and it is expensive and has poor water solubility.
However, the humanized collagen developed by Jinbo Bio for ten years has made a leap-forward breakthrough in acquisition technology. Developed the world's only humanized type III collagen with the original sequence of human collagen 100%, obtained the national recognized invention patent, and became the only successful case of collagen industrialization included in PDB data in the world. Humanized type ⅲ collagen can be widely used in medical care, medical beauty, skin care and other industrial fields because of its standardized raw materials and stable collagen structure, providing diversified application methods for consumption and medical scenes. At present, the functions of humanized type III collagen mainly focus on:
1. Tightening and wrinkle-removing effect: Studies show that with the loss of type III collagen, the original coarse type I collagen fibers form wrinkles on the surface skin. Therefore, effectively supplementing humanized type III collagen can form a connective tissue environment under our superficial skin, inhibit cell apoptosis, repair the original collagen fiber network, make the original wrinkles disappear from the superficial skin, and restore the firmness of facial skin.
2. Moisturizing and whitening effect: Jinbo type III collagen contains a lot of hydrophilic amino acids, and it is also the only collagen that has been proved to have the ability to bind water. With its stable triple helix structure and flexible bending structure of 146.88, it achieves a powerful water-locking and moisturizing effect. Moreover, according to the results of PDB, the cell adhesion rate of Jinbo humanized collagen III is 190% of that of natural collagen, which can activate the metabolic function of cells, reduce the pigmentation of superficial skin, avoid the formation of pigmentation and melanin precipitation, and achieve whitening effect.
3. Nourishing and anti-aging effect: After using Jinbo type III collagen, the SOD activity in skin tissue is significantly increased, and the MMP content in surface skin is effectively reduced, which is helpful to nourish surface skin and effectively reduce the loss rate of collagen, thus achieving the nourishing and anti-aging effect.
4. Safe repair efficacy: The influence of Jinbo human type III collagen on the survival rate of different cell lines is 0, and its structural sequence is consistent with that of type III collagen synthesized by human body itself, and there will be no rejection allergy caused by immune system attack, so it can form collagen network structure more safely, improve the metabolic ability of skin and realize self-repair of skin.
The decade of Jinbo Biology is a decade of vigorous development of functional proteins in China. In this decade, Jinbo Bio, together with Fudan University, Chongqing University and other scientific research units, has carried out numerous research and development, from interpreting the structure of collagen to screening functional regions, to the final gene recombination and in vitro expression of collagen. Each step seems simple, but countless researchers have made a lot of efforts. The final result must be to build an industrialized chain of humanized type ⅲ collagen at the world-leading speed, which will inject more powerful development momentum into the biomedical industry in China.