During my stay at Nagoya City University, I participated in the gene cloning and screening research of human and rat complement and more than a dozen complement-related factors and related proteins. Get a number of scientific research results. During my work in a biomedical research enterprise in Japan, I undertook the research and development of malignant tumor diagnostic kits, completed the declaration and listing in Japan, and participated in the formulation of relevant diagnostic standards of enterprises and countries. Participated in tumor biotherapy research and reagent development research, especially in the basic research of RNA interference, and achieved excellent results. In cooperation with Tokyo National Cancer Center, the research of peripheral blood stem cell transplantation has been carried out, and remarkable results have been achieved in large-scale chemotherapy for malignant follicular lymphoma, renal clear cell carcinoma and other malignant tumors. Participated in the research work of dendritic cells in biotherapy of malignant melanoma in the Institute of Advanced Medicine of Tokyo University. In August, 2003, he accepted the recruitment of talents from Liaoning Cancer Institute and resigned and returned to China. He entered the institute as the director of the biotherapy research department, and served as the deputy director of the biotherapy professional Committee of Liaoning Anti-cancer Association, the chairman of the tumor cell biology professional Committee of Liaoning Cell Biology Society, and the master tutor of Dalian Medical University. Engaged in clinical and basic research of tumor biotherapy, and obtained 5 provincial and municipal key projects. CIK and DC immune cell therapy, TIL, DC-NDV transgene, stem cell transplantation, tumor susceptibility gene detection for cancer risk assessment of healthy people, targeted therapy for cancer patients, and chemotherapy drug efficacy and toxicity prediction have been carried out, and good research results and therapeutic effects have been achieved. On the occasion of the 60th anniversary of the founding of People's Republic of China (PRC), he attended the National Day ceremony as a representative of overseas high-level talents and outstanding overseas returnees specially invited by the Central Organization Department, and was cordially received by General Secretary of the Communist Party of China (CPC) Central Committee Hu and Premier Wen of the State Council.