Hong Kui, Ph.D., professor, doctoral supervisor of School of Pharmacy, Wuhan University, and director of chinese society for microbiology.
Mainly engaged in the discovery and research of new drugs for marine microorganisms. Using genome sequencing and silencing gene activation, biological exploration, metagenome, selective separation, structure-oriented separation and other technologies, more than 5,000 high-quality mangrove microbial resources were collected in aspects of sampling ecology, strain type, compound type and biological activity evaluation. Bacterial groups include fungi with high activity in synthesizing natural products, such as Penicillium and Aspergillus, and Streptomyces, Micromonospora, Verruca, Actinomycetes, Microsporidia and Nonomura. In cooperation with natural products experts, more than 200 natural products were separated and identified, including more than 70 new compounds and more than 50 active compounds. Patent application 1 1, of which 4 were authorized, and more than 100 papers were published, including more than 50 SCI papers.
Director chinese society for microbiology, director of chinese society for microbiology Ocean Branch, director of China Biochemical Society Ocean Branch. He is a reviewer of Ijsem, Antonievanleeuwenhoek, Journal of Microbiology, Bulletin of Microbiology, Journal of Oceanography (English version), Forestry Research (English version) and other domestic journals.
Chinese name: Hong Kui
Nationality: China.
Occupation: professor, doctoral supervisor
Graduate school: Wuhan University
Main achievements: In cooperation with natural products experts, more than 200 natural products were separated and identified.
Masterpiece: First Prize of Excellent Papers on Natural Sciences in Hainan Province.
Gender: Female
outline
Study resume
1984.9 ——1988.7 Bachelor degree in microbiology, Department of Biology, Wuhan University.
1988.9 ——1991.7 postgraduate in the fermentation direction of tropical crops.
1995.9 ——1998.7 Doctor of Microbiology, Nanjing Agricultural University (Tsinghua University)
1998.11-kloc-0/999.7 Associate Research Fellow, Department of Applied Biology and Chemistry, Hong Kong Polytechnic University.
July 2000-2000.10 Associate Research Fellow, Department of Applied Biology and Chemistry, Hong Kong Polytechnic University
In 2004,11-2005.11won the KC-WONG China Scholarship of the Royal Society and visited HeriotWatt University and Newcatstle University in the UK.
In June 2009, he was sponsored by the British government to visit Plymouth Marine Laboratory.
20 13.7-20 13.9 EU Seventh Framework Project visited the Marine Natural Products Research Center of the Department of Chemistry, University of Aberdeen, UK.
Job resume
1991.7 ——1999.9 assistant professor, lecturer, senior associate professor, and assistant dean of technical college of processing department of South China University of Tropical Agriculture.
1999.9—2000.4 Associate Professor (Senior Professor) and Director of Research Office of Chinese Academy of Tropical Agricultural Sciences and South China University of Tropical Agriculture.
April 2000-April 2002 Associate Professor (Senior Professor), School of Environment and Plant Protection, South China University of Tropical Agriculture.
From May 2002 to September 2006, Professor Pi from the Chinese Academy of Tropical Agricultural Sciences and the State Key Laboratory of Tropical Crop Biotechnology of South China University of Tropical Agriculture.
September 20, 200610.12 Professor Pi, Institute of Tropical Biotechnology, Chinese Academy of Tropical Agricultural Sciences
20 10. 12—— Professor, School of Pharmacy, Wuhan University.
Academic part-time job
Director chinese society for microbiology, director of chinese society for microbiology Ocean Branch, director of China Biochemical Society Ocean Branch. Editors of domestic journals such as MarineDrugs, Amino Acids and Biological Resources, IJSEM, AntonieVanLeeuwenhoek, and long-term reviewers such as Journal of Microbiology and Bulletin of Microbiology.
Main research direction
research field
Marine microbial resources (strains, genes, compounds) and drug discovery
Interest and direction
1. Discovery and large-scale synthesis of natural products of marine microorganisms under the guidance of genomics (partial cooperation): On the basis of understanding the whole genome of microorganisms, explore the diversity of secondary metabolites synthesis of strains and improve the synthesis of target products. The research contents include: ① the whole genome sequencing of microorganisms (isolated from special environment, new taxa and producing new compounds) and the functional annotation of secondary metabolism-related genes; ② Isolation and identification of genes related to the synthesis of medicinal microbial active compounds; ③ Correlation between actinomycetes classification system and synthetic genes of secondary metabolites; (4) regulating the genes related to the synthesis of target compounds to improve the yield; ⑤ Activation of silencing genes and discovery of new secondary metabolites. The purpose is to explore the ability of microorganisms to synthesize natural products.
2. Separation and identification of active compounds of marine microorganisms (actinomycetes) under the guidance of medicinal chemistry (partial cooperation): Through understanding the chemical characteristics and efficacy of existing microbial drugs, from the collected microbial fermentation crude extract library, through chemical novelty, biological activity, secondary metabolic synthesis genes, strains and other aspects, the screening and separation scheme of target compounds was designed to separate, identify and discover new functional molecules of microbial drugs.
3. Isolation and identification of medicinal marine microbial resources (strains, genes) under the guidance of microbial systematics: On the basis of understanding the microbial classification system, the distribution law of medicinal microbial resources in different classification systems was found. Main research contents: ① Isolation and identification of medicinal microorganism (actinomycetes) resources; ② Biological activity detection and screening of metabolites of medicinal microorganisms (actinomycetes) (partial cooperation). ③ biogeography of actinomycetes. The purpose is to explore what kind of microorganisms have drug synthesis potential, and where (environment) do they usually grow?
project
2012.1-2014.12863 Sub-topic "Study on Medicinal Functional Genes of Marine Microorganisms in Mangroves" (20 12AA09220 1-5),
2012.1-2016.12 the seventh EU framework project (FP7), shortpharmasea (project 3 12 184) "Value-added and mobile marine life discovery pipeline"
2012.1-2015.12 National Natural Science Foundation of China 3 1 170467 Diversity and Geographical Distribution of Microorganisms in Mangrove Farming and Non-farming.
2011.7-2014.6863 Sub-topic 20 1a 09070 106 "Drug Evaluation of Reversing Multidrug Resistant Breast Cancer Compound HDZ- 137"
2011.1-2013.12 international cooperation project of national natural science foundation: soil actinomycetes and their bioactive substances in mangrove forests in coastal areas of Thailand/31/kloc-0.
2011.1-2013.12 Special fund for basic scientific research business expenses of central universities (starting fund for talent introduction of Wuhan University), 306-273450 "Discovery of lead compounds of marine microbial drugs guided by genome sequencing".
2011.1-2013.12 Sino-Thai cooperation project of the Ministry of Science and Technology: research on tropical marine and terrestrial actinomycetes resources by using culture and non-culture techniques (19-505J).
Major scientific research achievements
Performance summary
Mainly engaged in the discovery and research of new drugs for marine microorganisms. Using genome sequencing and silencing gene activation, biological exploration, metagenome, selective separation, structure-oriented separation and other technologies, more than 5,000 high-quality mangrove microbial resources were collected in aspects of sampling ecology, strain type, compound type and biological activity evaluation. Bacterial groups include fungi with high activity in synthesizing natural products, such as Penicillium and Aspergillus, and Streptomyces, Micromonospora, Verruca, Actinomycetes, Microsporidia and Nonomura. In cooperation with natural products experts, more than 200 natural products were separated and identified, including more than 70 new compounds and more than 50 active compounds. Patent application 1 1, of which 4 were authorized, and more than 100 papers were published, including more than 50 SCI papers.
Papers in international academic journals
1.ChaiH，YinR，LiuY，MengH，ZhouX，zhung，BiX，YangX，ZhuT，ZhuW，DengZ，hong k *； 6:27 18 1 . doi: 10. 1038/srep 27 18 1。
2. Streptomyces antarcticus isolated from the Arctic, a new species. intjsystevolmicrobiol . 20 16 Jan 19 . doi: 10. 1099/ijsem . 0.000907。
3.XieQY，RenJ，LiL，LiY，DengZX，HongK*。 antonievanleeuwenhoek . 20 16 apr； 109(4):483-9 1 . doi: 10. 1007/s 10482-0 15-064 1-x . epub 20 16 mar 4
4. Mustafa Ratebo, Yin Zhai, Emmanuel Hellner, Christopher. Rath, Wang Xiaoling, George Tabu Taravuth, Renbul, Melvin Bibu, Kouakou Keremet, Petraeus. Dores Tyne, Kui Hong, * Machel Jaspas *, Hayden *. Legonaridin，anewmemberoflinaridinrippfromaghanianstreptomycesisolate。 Organic 15(3):285-90.
6. Xu, Ma, Deng, Hong Kong. Genotype-driven isolation of endophytic antibiotics with new biological activities from Streptomyces 172205 in mangrove forest. applmicrobiolbiotechnol . 20 15 jul； 99( 14):5825-32 . doi: 10. 1007/s 00253-0 15-6574-5。 Epub20 15Apr 17
7. Yinzhai, Bincheng, Hu Juan, Kyeremeh, Kouakou, Wang Xiaoling, Spas, Marce, Hayden, Zi Dengxin, Kui Hong *, DraftgenomeSequenceOftreptomycessp. Strain CT 34, Isolated from Ghanian an soil sample, Genomeannouncements, 2065438+05FeB5; 3 (1). PII: E 01508-14. doi:10.128/Genoa.
8.LvC，QinW，ZhuT，WeiS，HongK*，Zhu，ChenR，HuangC。 Ophiobolinetatedfromographilusus induces g1ArrestofMCF-7 cells interact with kt/GSK 3β/cyclind 1 signal transduction. mard drugs . 20 15 Jan 16； 13( 1):43 1-43 . doi: 10.3390/MD 130 1043 1。
9.XuDB，YeWW，HanY，DengZX，HongK*。 NaturalProductsfromMa, ngrove actinomycetes. MarineDrugs.20 14， 12，2590-26 13； doi: 10.3390/MD 12052590
10.SunW，LvC，ZhuT，YangX，WeiS，SunJ，HongK *，ZhuW*，HuangC*。 Ophiobolin-oreversese cell cycle in human breast cancer cell line MCF-7/ADR. marine drugs . 20 13； 1 1:4570-4584.
1 1. Yuan Jiang, Hong, Lin, Xie, Li. The new Zalomycenfanalogsromangrovetresp.211726 with activityyagainst microbes and cancer cells. MarineDrugs.20 13， 1 1，8 17-829
12.LiT，DuYY，CuiQ，ZhangJT，zhw，HongK *，LiWL*。 Cloning, characterization and heterozygous expression of heindolocarbazole biosynthetic gene clusterrom marine-derived Streptomyces, MarineDrugs.20 13,1,466-488,
13., You Jumao, Qing, Zi Xindeng, Kwai Hong *. AntonievanLeeuwenhoek . doi 10. 1007/s 10482-0 13-9888-2
14.FuP，YangCL，WangY，LiuPP，MaYM，XuL，SuMB，HongK，*ZhuWM*。 Streptozoxazole and B, two new indolocarbazoles, are derived from actinomycetes. FMA
15.Learn-HanLee, Yoke-KqueenCheah, ShiranMohdSidik, Nurul-SyakimaAbMutalib, Yi-LiTang, Hai- Peng Lin, Molecular characteristics of Kuihong. Antarctic Inobacterium and screening of antimicrobial metabolites. World JMicrobiont. (2065438+02) 28: 2125 _ 2137. doi10.1007. s 1 1274-0 12- 10 18- 1
16. Peng, Xie, Qingyi, Hu, Huo, Hong, Kui, Todd, Jonathan. , Johnston, Lee,. Dimethyl sulfur-dependent dimethyl sulfur synthesis in mangrove soil. Canadian Journal of Microbiology, 58(4), pp. 523-530, 20 12/4.
17. Wang Junfeng, Lu Zhenyu, Pei Peiliu, Wang Yi, Li Jing, Kui Hong *, Wei Mingzhu *. Cytotoxic polyphenol Fromthenggunspenicillime xpansum091006 Endogenous with the mango. PlantExcoecariaagallocha，plantad 20 12； 78: 186 1_ 1866
18., Lu Zhenyu, Hai, Liu Peipei, Du Miao, Tong Hanzhu, Kui Hong * and Wei Mingzhu *. Antimicrobial aflatoxin 092008 from marine derived fungi. ArchPharmResVol35, No.8, 1387- 1392, 20 12.
19.XieQY，LinHP，LiL，BrownR，GoodfellowM，DengZX，HongK*。 AntonievanLeeuwenhoek(20 12) 102: 1 _ 7。 doi 10. 1007/s 10482-0 12-9707- 1
20. Yang, Lu, Meng, Wei, Hong, Zhu and Huang. Then by activating MAPK signal transduction pathway. Bio-organic oi10.1007/s10482-011-9571-4.
32.XuXX, QuZ, WangHL, LinHP, WangC, XieQY, RuanJS, and hongk *. asanohainanensis sp. nov, isolated from Rhizosphere Soilofacile, . intjsystevolmicrobiol 20 1 16 1，2384 _ 2388 . doi: 10. 1099/ijs . 0.025825-0
33.SuiJL、XuXX、QuZ、LinHP、RuanJS、HongK*。 intjsystevolmicrobiol . 20 1 16 1(7): 1632 _ 1637
34.WangF，XuXX，QuZ，WangC，LinHP，RuanJS，HongK*。 IntJSystEvolMicrobiol，20 1 16 1: 1304 _ 1308 . doi: 10. 1099/ijs . 0.025742-0
35.XieQY，WangC，WangR，QuZ，LinHP，GoodfellowM，andHongK*，Jishengellaendophyticagen.nov .，sp.nov .，anewmemberofthefamily micromonosporaceae， intjsystevolmicrobiol . 20 1 1，6 1， 1 153 _ 1 1 159.0
36.ChenGD，GaoH，TangJS，HuangYF，ChenY，WangY，ZhaoHN，LinHP，XieQY，HongK，LiJ， Yaoxs *. Benzamidesandquizzlines from Amangrovalimentisttreptomycessp. (No.061316) and their inhibition of caspase-3 -3catalyticactivityinvitroChem. Pharm.Bull.20 1 1，59，447—45 1。
77.WangC, XuXX, QuZ, WangHL, LinHP, XieQY, RuanJSandHongK*, micromonospora, new species, isolated from mangrove soil. IntJSystEvolMicrobiol，20 1 16 1，320_324。
38.YuanGJ，LinHP，WangC，HongK*，LiuY， lij . the 1 hand 13 resonanceofwonewmacrocyclinesis isolatedfromphrymessp . 2 1 1 726 andrevised assignmentsofazalomycinsf3a，F4aandF5a .magneticresonaceinchemistry . magn . reson . chem . 20 1 1，49，30_37。 doi: 10. 1002/MRC . 2697
Authorized patent
1. Hong Kui, Xiao Chun, "A Rapid Method for Detecting Antibiotics Against Yeast Fungi", PatentNo.: ZL03 128096.
2. Zhu Weiming, Hong Kui, Miao Chengdu, Sesquiterpene-like compounds and their preparation methods and uses, application number 2008 10 172946, application date: 2008.438+00.24. Publication number: cn101591314a; Publication date: 2009.12.2; Patent number: ZL2008 10 172946.0
3. Hong Kui, Yuan Ganjun, Lin Haipeng, Xie Qingyi, Huang Xiaolong, Tang Yili. Novel azamycin F macrolide compounds, their preparation methods and applications. ZL2009 10253892.5
4. Hong Kui, Zhu Weiming, Sui, Xu, Wang _. Novel cruciferous alkaloid analogues, and preparation method and application thereof. ZL 20 12 10 185370.9
5. Yao Xinsheng, Li Jia, Hong Kui, Tang Jinshan, Gao Hao, Gao Lixin, Lin Haipeng, Zeng Xuerong, Li Sheng and Zhuang Ling. Application of styryl phenol compound as insulin sensitizer, application number: 201010230436.1,application date: 206538.
6. Use of Yao Xinsheng, Li Jia, Hong Kui, Tang Jinshan, Gao Hao, Gao Lixin, Lin Haipeng, Zeng Xuerong, Li Sheng and Zhuang Ling 2- acetylaminocholic acid as insulin sensitizers, application number: 201010230421.5, application date: 2000.
7. Yao Xinsheng, Hong Kui, Li Jia, Tang Jinshan, Gao Lixin, Chen, Xie Qingyi,. Application of a compound with Caspase3-3 inhibitory activity, with the application number of 2010/0230402.2 and the application date of 20 10.7. 16.
8. Hong Kui, Zhu Weiming, Sui, Xu, Wang _ New Cruciferae alkaloid analogues, their preparation methods and applications. Application number: 2010/0185370.9, application date: 2010.5.20;
9. Hong Kui, Yuan Ganjun, Lin Haipeng, Xie Qingyi, Wang Cheng. Novel oxygen-containing heterocyclic compounds and their salts, their preparation methods and uses. The application number is 2010174352.0, and the application date is 20 10.4.27.
10. Zhu Weiming, Zhuang Yibin, Hong Kui,,, Wang _, Liu, Fu Peng, cresol trimer compounds and their preparation methods and uses, with the application number of 20101271750. Date of application: 20 10.2.22
1 1. Zhu Weiming, Xu Zhihong, Hong Kui,,, Wang _, Liu, Fu, Zhang, quinazolinone alkaloids and their preparation methods and uses, with the application number of 20 10 1004562.5. Date of application: 20 10. 1. 10.
12. Zhu Weiming, Fu Peng, Hong Kui, Wang _, Liu, bipyridine alkaloid, its preparation method and application, application number 2009 10258693.3. Date of application: 2009. 12. 17
13. Hong Kui, Yuan Ganjun, Lin Haipeng, Xie Qingyi, Huang Xiaolong, Tang Yili. Novel azamycin F macrolide compound, its preparation method and application, application number: 2009 10253892.5, application date: 2009.6438+065438. Publication number: CN 10 1792474A, and publication date: 20 10.08.04.
14. Hong Kui, Xiao Chun, "A Rapid Detection Method of Antibiotics Against Yeast Fungi", (A Method for Detecting the Biological Activity of Yeast-like Pathogens in Arabic). Patent number: ZL03 128096
15 Hong Kui, Meng Huiying, Chailing Town, Yin Ru, Deng. The synthetic gene AuOS of Ophiopogon japonicus saponin compound mother nucleus and its application. The application number is 201510130163.6, and the application date is 20 15.3.24.
16. Hong Kui, Han Ying, Tian Erli, Deng. A strain with high yield of olive leaf compounds, and its preparation method and application. The application number is 20 15 10260295.0, and the application date is 20 15.5.20.
17. Hong Kui, Ye, Deng. Preparation method and application of compound with activity of inhibiting A beta aggregation. The application number is 2015011510.4, and the application date is 20 15.4.0 1.
18. Hong Kui, Xu, Deng. Preparation method and application of compound with activity of inhibiting A beta aggregation. The application number is 20 14 10499832.2, and the application date is 20 14.9.25.
Pan Jie hong kui 19. Streptomyces TKPJ3039 with high yield of azamycin F compounds and its application, ZL 201310195438+01.4 Date of authorization: 201488+04194.
20. Hong Kui, Yang Xue. A strain of Aspergillus oryzae TKYX429 with high yield of herbaceous compounds and its application, ZL 201310186483.4 Authorized date: 20 14.