Duke University's best majors are business administration, environmental engineering, evolutionary anthropology, English, linguistics, mathematics, computer science, cultural anthropology, economics, global cultural studies, global health, history, international comparative studies, biophysics, sociology, drama studies, visual arts, chemistry, civil engineering, classical civilization, neuroscience, philosophy, physics, political science, psychology and women's studies.

Duke University ranks ninth among the best universities in the United States and first in the southern United States. Higher education universities in the world rank 23rd, and academic ranking of world universities ranks 3rd1in 2022. This shows the strength of these majors in Duke University.