Born in February, 1964, from Anxian County, Sichuan Province. 1985 after graduating from the department of physics in Peking University, he went to study in the United States through the Li Zhengdao project and obtained a doctorate in theoretical physics from the Massachusetts Institute of Technology. At present, he is a professor at the University of California, San Francisco, and a professor at the Yangtze River Department in Peking University. He made outstanding contributions in the field of statistical physics and condensed matter theory in his early days. During his Ph.D., he developed a general method to calculate the thermodynamic Casimir force between two objects with arbitrary shapes in long associated liquid by using field theory technology (Li and Caldal, Phys. Rev.lett1991), and it has been widely used. During his doctoral and postdoctoral years, he published a series of important articles on the critical phenomena of thin films, polymers and inelastic collision multi-particle systems. 65438+turned to biophysics, bioinformatics and systems biology at the end of 1990s. He has done a series of pioneering work in protein folding and design, genome analysis, gene regulation network and other fields, and became one of the first few physicists in the United States to receive tenured professors in a few medical schools. 1996 analyzes protein's folding and design problems with statistical physics, and puts forward the designability principle of protein folding, which has been widely concerned and applied in this field (Li et al. Science 1996). In 2000, Bussemaker et al. (PNAS 2000) proposed a method to identify functional fragments of genome by constructing a gene dictionary, which was reported in PBS's "The Secret of Genes" series of TV programs. In 2009, a series of quantitative methods were proposed to study the dynamic behavior and evolution of gene regulatory networks (Tuch et al. PLoS Biology 2008Chin et al., PLoS Biology 2008). This research work was supported by the National Institutes of Health, Packard Research Fund and Sandler Foundation. In 20 10, he was funded by the highly competitive NIH director transformation R 0 1, and was reported by NIH publications, UCSF publications and San Francisco Business Times. He has published 60 papers in journals such as science, nature, natural genetics, PLoS Biology, Proceedings of the National Academy of Sciences (PNAS), phys.rev.lett, etc., and has been cited by SCI for more than 3,700 times.