Purdue University has strong engineering strength. Since 1878, Purdue University has been one of the five universities that awarded the most engineering undergraduate degrees, and it is also the university that awarded the most engineering degrees to women. One in every 50 engineers in the United States graduated from Purdue University. The majors offered by its engineering school cover aerospace, agriculture, biology, biomedicine, chemistry, civil engineering, architecture, electronics, computer, industry, materials, machinery, atoms, exploration and some interdisciplinary subjects. In 20 13 ranking of graduate schools, American news and world report ranks its engineering school in the third place according to employment situation and the eighth place according to comprehensive strength. Among them, industrial engineering, civil engineering, aerospace engineering, mechanical engineering, electronic engineering, computer engineering, biological engineering, agricultural engineering, and nuclear engineering are all in the top 10 in the United States. Purdue University ranks among the top 25 in the United States in all other engineering projects, including materials engineering and biomedical engineering. Engineering students who graduated from Purdue University are very popular with employers. For example, at General Motors, more employees graduated from Purdue University than from any other American university.

Purdue University's management major also enjoys a high reputation all over the world. According to comprehensive strength, American News and World Report ranked 53rd in Krannert Graduate School of Management, 3rd in production/operation management, 4th in quantitative analysis, and 10 in supply chain management. In 2002, the Financial Times ranked the MBA program of Lannert School of Management as the fourth in the world according to its geographical distribution, and the sixth in the United States and the eighth in the world according to the students' achievement of their goals. In addition, Purdue University's computer science, chemistry, statistics and mathematics are among the best in the United States.