Fudan University, Suzhou University, Sun Yat-sen University, Shandong University, Anhui Medical University, University of Science and Technology of China, Shenyang Normal University, Xuzhou Medical College, China Academy of Sciences, Zhengzhou University.

The study of nervous system often needs the combination of high resolution, depth imaging and large section visualization. It is also necessary to flexibly handle different types of samples, such as living cells, tissues, organic compounds and model organisms.

The study of fast dynamic processes, such as cell transport or synaptic remodeling, requires high-speed microscopy. One of the main challenges of high-speed microscope is to obtain high-resolution images while avoiding fluorescence saturation.

Neuroscience research usually involves large field of vision and stereo imaging. The need to reduce fluorescence scattering and background signals makes it difficult to obtain images with high contrast and resolution, which is especially critical when examining neuronal structures in dense tissues such as brain slices.