According to its own advantages, the hospital dug deep into its potential, founded a brand of science and technology, and successively formed specialties such as respiratory medicine, urology, endoscopic surgery, thoracic surgery, pediatric hematology, cardiology, alopecia treatment, and liver disease diagnosis and treatment. Guangzhou Institute of Respiratory Diseases is located in the hospital, which is currently headed by Professor Zhong Nanshan, academician of China Academy of Engineering and president of Guangzhou Medical College. The Institute has several clinical departments, such as Respiratory Medicine, Thoracic Surgery, Guangzhou Respiratory Monitoring Center (Respiratory Monitoring Department) and Experimental Department, which are specialized in the research and clinical diagnosis and treatment of respiratory diseases. Especially in the fields of asthma, respiratory failure, pneumonia (pulmonary infection), tuberculosis, emphysema, chronic bronchitis, bronchial foreign body removal, lung surgery and thoracoscopic technology, the application of fiberoptic bronchoscopy in the diagnosis and treatment of respiratory diseases, and the basic research and prevention of lung cancer. , enjoys a high reputation at home and abroad. Especially the Respiratory Disease Monitoring Center (RICU) is one of the top ten projects of Guangzhou Education Foundation. The center is equipped with isolation beds, advanced laminar air purifier and central air conditioning system, which effectively realizes indoor air purification and greatly reduces cross-infection between patients through air transmission. Adopt integrated air source and power supply machine to ensure the safe work of monitoring system; The center purchased the monitoring system of American Space Laboratory Company, which can continuously monitor patients' circulatory dynamics, respiratory dynamics and nutritional metabolism. It can automatically analyze all physiological indexes of patients and cooperate with computer network system to realize global monitoring; There is a multifunctional ventilator in the hospital to meet the ventilation requirements of all kinds of patients; The ventilator is connected with the computer, and all adjustment and measurement parameters can be automatically recorded and saved. The modern management of guardianship in the Institute of Respiratory Diseases provides the safest and most scientific guarantee for the treatment and rescue of patients.

Another most distinctive department in the First Hospital of Guangzhou Medical University is endoscopic surgery, which is a medical instrument that combines physical and optical principles with mechanical structure. It can introduce people's vision to tissues and organs that needed open surgery in the past. Endoscopic surgery is a method of observing deep tissue lesions through several incisions (commonly known as "keyhole") in the patient's body and performing surgical treatment with microsurgical instruments. Endoscopic surgery is more and more popular with patients because of its advantages of less trauma, rapid postoperative recovery, low infection rate and short hospitalization time, and it has developed rapidly all over the world.

Endoscopic surgery in the First Hospital of Guangzhou Medical University started earlier. Entrusted by the Central Ministry of Education, Professor Wu Kaijun, a physician in the First Hospital of Guangzhou Medical University, went to the University of Pittsburgh Medical College as a visiting scholar to study urology, and devoted himself to the research of endoscopic surgery, which gave him the opportunity to get in touch with this new technology. After Wu Kaijun returned to China, he vigorously promoted this new treatment technology and conducted a series of research and development. Entrusted by the Ministry of Health, the first class of endourology was held under the auspices of Wu Diwen Kaijun. More than 100 experts from major hospitals in China participated in this study.