The difficulty of postgraduate entrance examination for nursing majors in Guangzhou University of Traditional Chinese Medicine depends on many factors, such as admission scores, professional rankings, school rankings, postgraduate admission ratio, enrollment, school popularity, etc., and the difficulty directly affects whether candidates can succeed in postgraduate entrance examination, so the difficulty of postgraduate entrance examination is a factor that cannot be ignored in the postgraduate entrance examination process. The ranking of nursing specialty in Guangzhou University of Traditional Chinese Medicine is a factor that cannot be ignored. The high ranking of nursing specialty means fierce competition, which will inevitably increase the difficulty of postgraduate entrance examination. In addition, cross-majors will also increase the difficulty of postgraduate entrance examination, especially liberal arts and cross-science, which is still very difficult for postgraduate entrance examination with only one year of review. It is hoped that candidates will make a comprehensive analysis of the difficulty of the postgraduate entrance examination for nursing major in Guangzhou University of Chinese Medicine through various channels such as communication with graduate students, forum for postgraduate entrance examination, Baidu exchange and group exchange. Only in this way can they finally become graduate students successfully.