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The mid-term inspection report of the thesis is model essay 1: the surname of the special class is Xue.

College: Industry: Grade: Name:No.:

Instructor:

I. Work progress and tasks

1. After the opening report, Comrade Zhang summarized the mid-term preparation work and gave a brief guidance on the next step; 2. Preparation of metallographic samples

(1) metallographic examination is one of the important methods to study the internal microstructure of metals and alloys. In order to observe the internal microstructure correctly and effectively under metallographic microscope, it is necessary to prepare a metallographic sample for microscopic examination. It can also be called a grinding disk. The main procedures for preparing metallographic samples include sampling, polishing, polishing and etching. (2) Sampling principle: a small part of metal is sampled manually by metallographic microscope. Its success can be said to depend on the metallographic study of a small part of metal by hand with a metallographic microscope, and its success can be said to depend on whether the samples taken are representative. Generally speaking, metallographic samples for studying the microstructure of metals and alloys should be taken from the most important parts of materials or parts in use; Or the part with the most serious defects such as segregation and inclusion. When analyzing the failure reasons, samples should be taken from the failure parts and complete parts to explore the failure reasons. For parts with long cracks, samples should be taken from the crack starting point, extension and crack tail to analyze the causes of cracks. When studying the parts after heat treatment, the samples can be cut at will because of the uniform structure. If you study oxidation, decarburization and surface treatment (such as carburization), you should intercept the sample in the cross section (3): No matter what manual interception method you adopt, you must ensure that the metallographic structure of the observation surface of the sample will not change. Soft materials can be cut by sawing, turning and planing. Hard materials can be cut by water-cooled grinding wheel slicer and EDM. Hard and brittle materials (such as white cast iron) can also be obtained by hammering. For the sample whose surface treatment depth is to be measured, the cutting surface should be perpendicular to the infiltration surface. When studying rolled materials, such as the shape and type of inclusions, the degree of deformation of materials, the degree of grain elongation and banded structure, longitudinal samples should be taken parallel to the rolling direction. In order to study the surface defects of materials and the distribution of nonmetallic inclusions, transverse samples should be cut in the vertical rolling direction. The ideal shape of metallographic samples is cylindrical and square, depending on the specific situation. The general height is 10 ~ 15 mm, and the diameter is φ1o ~15 mm; The side length of a square sample is10 ~15 mm. In practical work, due to the variety of materials and parts, it is difficult to intercept the ideal shape and size of materials and parts, which can generally be determined according to the actual situation. However, it is appropriate to take the height of the sample as half of its diameter or side length, and the shape and size are convenient to hold in your hand for grinding. (4) Sample grinding: the purpose of manual polishing.

Rough grinding: soft materials can be leveled with a file by hand, and general materials can be leveled with a grinder. During operation, the side of the grinding wheel should be used to ensure the level of the sample. It should be noted that the contact pressure should not be too high, and the water should be continuously cooled to prevent the internal structure from changing due to temperature rise. Finally, when chamfering, it is necessary to prevent the sandpaper from being cut during fine grinding. However, it is necessary to observe that the surface samples such as decarburization and carburization cannot be chamfered, and sometimes electroplating is used to prevent the edges of these samples from chamfering. After the rough grinding is completed, all samples should be chamfered.

In the later process, sandpaper or polished objects will crack. It may even be caught by polished objects and thrown out, causing accidents.

Fine grinding: The purpose of manual fine grinding is to eliminate the deep and coarse grinding marks left by rough grinding and prepare for polishing. Fine grinding itself involves multiple operations, that is, from coarse to fine on each number of sandpaper. Hand-finished abrasives are sandpaper, which is divided into various specifications and numbered according to the size of abrasive particles. Manual hand grinding method is to use flat glass plate or flat iron plate to push grinding on metallographic sandpaper. In order to ensure that the test surface of the sample is flat and does not generate arc, the force applied to the grinding surface should be balanced and the grinding surface should be in complete contact with sandpaper. At the same time, the grinding should be carried out in one direction, and the sample should be lifted away from the sandpaper when pushing forward. Fine grinding generally starts from No.0 (w40), and fine sandpaper is changed one by one. Generally, steel samples are polished into No.04 sandpaper, and soft materials such as aluminum and magnesium can be polished into No.05 sandpaper. When replacing fine sandpaper, you should clean the glass plate under the mat to prevent coarse sand particles from falling into fine sandpaper, and at the same time, rotate the grinding direction by 90 to observe whether the last grinding marks are worn off. When finely grinding soft metallographic samples, non-ferrous metals such as aluminum, magnesium and copper should be coated with a layer of lubricant on sandpaper to prevent sand grains from being embedded in soft metallic materials and reduce surface tearing. Commonly used lubricants are engine oil, paraffin, gasoline solution, gasoline and saponified matter.

No. 1. 12. 1

Furnace number 2J061022J0101

Steel grade 16mndr 16mndr

Specification mm 1260

The sample direction is transverse.

Lower yield strength tensile strength

38234 1

5365 13

Elongation 3 129.5

No. 1. 1

Impact temperature-10-20-30-40-50

Shock 96422824287945 163

Influence 2376295

Impact 3822223721376137

The average value is 742222299 14844

MetallographicNo.10112

Remarks: 1∕4 plate edge center

1.2- 10-20-30-40-50

2. 1- 10-20-30-40-50

202 122

Center of plate edge 1∕4

2.2- 10-20-30-40-50

Draw the curve of impact performance and temperature in the order of the above data:

Second, the reasons for not completing the task as planned

be sold out

Third, the problems encountered in the work and improvement measures

Data processing, learn the origin data processing method, and successfully draw the change curve. Fourth, the next work plan.

Polishing from the 9th week to the 10 week, preparing samples to be observed, taking photos, observing and analyzing the mechanical properties of 16mndr low-temperature pressure steel in the 1 10 week.

The purpose of sample polishing is to remove the grinding marks left by fine grinding on the grinding surface of metallographic samples and become a smooth and flawless mirror.

Although polishing is the last process of metallographic sample preparation, the experience of metallographic workers is that the polishing process of metallographic samples needs more efforts, because polishing can only remove a thin layer of metal on the surface, so the polishing result depends largely on the quality of the previous process. Sometimes, before polishing, a small number of deep wear marks will be left on the grinding surface, which is difficult to remove even if the polishing time is increased. Generally, it must be re-polished. Therefore, it is necessary to carefully check the grinding surface before polishing to see if there are uniform fine grinding marks in a single direction. Otherwise, it should be re-polished to avoid wasting time. This is an important link to improve the efficiency of metallographic sample preparation.

Fan Wen-er: Multi-scale finite element analysis and experimental study on the subject structure of engineering mechanics and ocean engineering instructors in the School of Woodworking Engineering of famous schools (departments)

Interim report date: 2065438+March 26th, 2003, signed by the inspection team leader.

Graduate School Training Office System

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1. The interim report of the master's thesis will be made at the end of the third semester or the beginning of the fourth semester after the master's entrance; 2. After the report is signed and approved by the interim report inspection team leader, it shall be submitted to the graduate teaching secretary of the hospital (department) for the record;

If you really can't finish your thesis work on time, you need to apply for an extension two months before the normal graduation time.

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Master's degree thesis supervisor evaluation record

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Explanation of revision of master's degree thesis

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Attachment 1-4

Record Form of Postgraduates' Published Papers

Attachment 1-5

Feedback form of master's degree thesis inspection team

Paper 3 Mid-term Inspection Report Fan Wenyi, Design Progress (Paper)

1, after preliminary study and requirement analysis, I probably mastered the writing process of java programs, the use of frameworks in java, and the understanding of databases, and became familiar with the relationship between java programs and databases.

2. The system is comprehensively analyzed, and the demand analysis and functional module design are carried out. The relationship between system and database is systematically analyzed and designed. Optimized the design of the examination table in the database.

3. The design of database is realized, with 8 database tables. Examination form for examination candidates. Multiple-choice table, JCloze fill-in-the-blank table, appraisal table, Jquiz short answer table, multiple-choice answer table, JCLOZE fill-in-the-blank answer table, appraisal answer table, etc.

4. Different types of questions have been extracted and combined according to the difficulty setting.

(1) The administrator logs in and enters the test questions.

(2) The administrator manages the test questions in the database, such as deleting and modifying.

(3) Students can get an automatically assigned test paper from the system after logging in.

(4) After logging in, teachers can see the candidates' papers and grade them.

(5) Examination papers submitted by candidates can be graded automatically, such as multiple-choice questions and fixed questions.

5. The translation of 3000-5000 words of foreign language materials related to this major has been completed.

Second, the existing problems and solutions

1. The existing problems are: the authority of managers, the authority of students and the authority of teachers.

The solution is to retrieve data from the database according to the entered user name and password, and save it as a session according to the user's permission value. When you open a new page, determine the session.

2. The existing problem is that the examination questions are assigned immediately.

The solution is: when designing the database, set a keyword in each question table to distinguish the selected questions.

3. The existing problems are: the judgment, filling in the blanks and automatic comparison of multiple-choice questions in candidates' test papers.

The solution is to add an answer table and set the keywords of the table associated with it.

4. The problem is that when designing the database, after the candidates finish the exam, the exam papers answered by the candidates cannot be correctly related to the exam questions.

The solution is to set the primary foreign key to connect tables.

5. The existing problems are: system security.

The solution is:

(1) Use the security management measures of the database itself and windows security management measures.

(2) On the system resource access, add a filter to verify the identity, so as to achieve reliability.

Third, the later work arrangements

1. Get the assigned questions as soon as you continue to complete the exam, and the difficulty of the questions fluctuates during the exam.

2. Focus on the distribution of test questions.

3. Test the permissions of different people. If you log in with different identities, you can only see the corresponding pages, which constitutes a test report document.

4. Improve the security of the system. And test it to form a test report document.

5, the system acceptance test, and constitute a test report file.

6. After the completion of the system, under the guidance of the tutor, aiming at the development of this system, the existing problems.

And summarize the experience of system development, and write a paper of about 15 thousand words as a report and summary of the completed graduation project.

Mid-term inspection report, model article 4 (1), research progress.

Kawasaki disease is an acute, self-limiting systemic vasculitis, which occurs mostly in infants under 5 years old. It was first discovered in Japan in 1962 and first reported by Japanese scholar Kawasaki Fuyu in 1967. Since then, it has been reported in Europe, Asia, America, Australia and South Africa. Because the etiology of this disease is unknown and its clinical manifestations are complex, it can involve many systems of the whole body, especially coronary arteries. It has replaced rheumatic fever as the most common disease of children's acquired heart disease in Japan and the United States, and it has become one of the most common acquired heart diseases in children at present, and may be one of the risk factors of adult ischemic heart disease. In recent years, KD has made a lot of progress in epidemiology, etiology, pathogenesis and clinical diagnosis and treatment. According to the content of the scheduled opening report and the reasonable arrangement of the schedule, this paper analyzes and summarizes the relevant literature review and research status at home and abroad, which lays a theoretical foundation for the research of this paper.

(2) The research work and achievements that have been completed so far.

This paper selects relevant cases in advance. In this paper, 20 children with Kawasaki disease, with an average age of (2. 10/0), were selected from June 2065438 to July 2065438+July 2004 in Renhe Hospital of Three Gorges University, Yichang Central Hospital and Yichang Second Hospital. The inspected objects are numbered according to the selected order, for example, 1 The number of the selected objects is 1. Diagnostic criteria are Kawasaki disease diagnostic criteria formulated by American Heart Association:

1) fever lasts for more than 5 days, and antibiotic treatment is ineffective, which cannot be explained by other known diseases;

2) Conjunctival congestion (non-exudative);

3) chapped lips, diffuse congestion of oral membrane and bayberry tongue;

4) erythema multiforme and furuncle;

5) Acute scleredema of hand and foot and erythema palmaris; There is membranous desquamation at the skin transition of nail bed at the end of finger (toe) in recovery period;

6) Acute non-suppurative cervical lymph nodes are large, often unilateral, with a diameter of >100 mm; 1.5cm or more.

If the above criteria meet at least 5 items, it can be diagnosed as Kawasaki disease, in which 1) is a necessary condition. If the child has unexplained fever for more than 5 days, accompanied by three other diagnostic criteria, and coronary artery dilatation or coronary artery aneurysm is confirmed by two-dimensional echocardiography or coronary angiography, besides other diseases, diagnosis can also be made. The general data of all patients were fully counted, and on this basis, patients were randomly grouped.

Interim report on master's degree thesis of Three Gorges University

Lay the foundation for the follow-up research.

(3) The research work and progress to be completed in the later period.

In the later stage, we will first detect the specific cells expressing CCL5 and CCR5 in children with KD. 3- 4 ml peripheral blood was collected from KD children and normal control group, and PBMC:3-4ml sterile heparin sodium was isolated for anticoagulation, and Ficoll's method was used.

Peripheral blood mononuclear cells (PBMCs) were isolated and extracted by density gradient centrifugation. While analyzing and detecting bases

Based on the above, the result analysis includes:

1) to identify the specific expression cells of CCL5 and CCR5 in peripheral blood PBMC;

2) What are the changes in the expression levels of CCL5 and CCR5 in T cells before and after activation?

3) To understand the relationship between CCL5 and CCR5 in children with Kawasaki disease.

Through the above comparison, the expression changes of CCL5 and CCR5 in peripheral blood of children with Kawasaki disease were studied, which provided new ideas for the pathogenesis and treatment of Kawasaki disease. The research results are shown in the following table:

Effect of Epitope 1 Chemokine CCL5 on T Cell Chemotaxis

Vision 0 10 20 50 100 300 500

①2 1 50 88 57 60 52 33

②26 45 82 57 60 36 36

③ 12 44 43 14 32 60 6 1

④40 76 55 69 6 1 57 66

⑤ 19 55 63 29 53 43 50

⑥ 14 55 76 23 40 46 53

⑦ 17 35 59 4 1 55 30 30

⑧9 33 47 65 32 38 47

⑨ 13 14 25 20 30 36 29

Total171407 538 375 423 398 405

Mean/visual field19.09.445.217.259.820.10.620.947.013.344.210.345.060.

Table 2 Effect of CCR5 Blocker on T Cell Chemotaxis

Vision 0 10 50 100 200

①50 30 18 13 10

②38 23 13 12 9

③44 19 12 5 5

④72 25 17 5 7

⑤78 27 9 7 9

Total 282 124 69 42 40 average/visual field 56.417.63 24.8 4.1513.8 3.708.4 3.858.0 2.0.

Through the influence of chemokines CCL5/ CCR5 on T cell chemotaxis, our experimental conclusions are as follows:

1 and chemokine receptor CCL5/ CCR5 are highly expressed in peripheral blood of children with Kawasaki disease, suggesting that they may be closely related to the occurrence and development of peripheral blood in children with Kawasaki disease. In addition, receptor CCRS may be one of the signs of Kawasaki disease.

2. Chemokine receptor CCL5 is obviously expressed in peripheral cells of children with Kawasaki disease, and it is a functional receptor.

Ten concentrations are obvious.

3. Ca in SACC-83 cells after adding chemokine CCLS in the experimental group.

2

Instantaneous rise phenomenon (see figure 1), and the cell surface was changed by using receptor CCRS blockers Maraviroc and CCRSmAb.

The concentration of 10 has no obvious fluctuation (see figure). After the receptor CCRS was blocked, intracellular Ca was found by tracking and monitoring.

2

1)。

4. The chemokine CCLS can promote the mobility, invasion, chemotaxis and proliferation of peripheral cells in children with Kawasaki disease after binding with its receptor CCRS. The mechanism may be that CCL5/ CCR5 biological axis initiates calcium-related signals in cancer cells by causing changes in intracellular calcium concentration.

(4) Existing difficulties and problems

Chemokines, as a member of cytokine superfamily, are a kind of small molecule protein with directional chemotaxis to cells, which can attract immune cells to participate in immune response and immunopathological process [12]. Up to now, at least 50 chemokines have been found, which are composed of 70- 125 amino acids and have a molecular weight range of 8- 1 1KD. Most chemokines contain two characteristic disulfide bonds formed by four conserved cysteines, so they have very similar high-level structures. C-terminal is α-helix, N-terminal is irregular, and it has high biological activity and binds to receptor.

Chemokines were first discovered as chemokines, but with the in-depth study of chemokines, it is now recognized that chemokines not only have chemotactic effects on white blood cells, but also play a wide range of physiological and pathological roles in the development of immune cells and organs, immune response process, inflammatory reaction, pathogen infection, wound repair, tumor formation and metastasis [14- 16]. With the in-depth study of chemokines and their receptors in recent years, many scholars at home and abroad have found that their combination plays a role in the recruitment and chemotaxis of T cells in autoimmune diseases, and the corresponding T cells gather in target organs to cause tissue and organ damage. Wensel et al. found that CXCL 10 combined with its receptor CXCR3 can directionally recruit cytotoxic T cells into the target organs, and eventually lead to skin damage. Barone et al. showed that the expressions of CXCL9, CXCL 10, CXCL 1 1 and receptor CXCR3 in corneal epithelial cells of lacrimal gland in patients with Sjogren's syndrome (SS) all increased. Goulvestre et al. found that the expressions of CCL2 1, CXCL 12, CXCL 13 and CCL22 increased in thyroid tissues of patients with autoimmune thyroid diseases (AITD), among which CXCL 12 was formed by ectopic secondary lymphoid follicles in thyroid tissues of autoimmune diseases.

Interim report on master's degree thesis of Three Gorges University

The expression of CXCL 13 and CCL22 increased significantly. At present, the research focus on chemokines and their receptors is chemotaxis.

Chemokines play a role in recruiting and chemotactic T cells to target organs in autoimmune diseases, but there are few studies on their specific functions in Kawasaki disease. At present, there are few studies on the expression and significance of chemokine CCL5 and its receptor CCR5 in Kawasaki disease, lacking the support of relevant literature and data guarantee. At the same time, the content and extraction method of this study are relatively complicated. Therefore, we need to invest more energy and time in the research to ensure the rationality and accuracy of the research results, and at the same time, we need to further collect and sort out the literature, especially foreign literature, to lay the foundation for this research.

(5) Possibility of completing all papers on schedule.

At present, some research objects have been collected, and the corresponding grouping and blood collection have been carried out. At the same time, domestic scholars have studied the expression of CCL5 and CCR5 in other diseases, which can provide corresponding research methods and route reference. However, the authors have isolated PBMC and successfully activated and proliferated T cells. Therefore, the follow-up work can be completed according to the initial progress, and the quality of research and the accuracy of conclusions can be guaranteed.

Lecturer's comments:

Comments of the review team:

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