As the person in charge, Professor Jiang Xuehua completed the project of National Natural Science Foundation "Study on the Quality Evaluation of Organ-targeted Nanoparticle Drug Delivery System for Anticancer Drugs" and the project of National Doctor of Medical Technology Innovation "Study on Liver-targeted Akramycin A Nanoparticles and Freeze-dried Injection of Akramycin A Polylactic Acid Nanoparticles with Liver-targeted Characteristics", carried out the research on the quality evaluation of Organ-targeted Nanoparticle Drug Delivery System, and put forward the indicators and methods for the quality evaluation of Organ-targeted Nanoparticle Drug Delivery System.
Professor Jiang Xuehua is in charge of clinical pharmacokinetics research and bioavailability evaluation research of nearly 100 new drugs, and has done a lot of exploratory work for the first phase clinical research of new drugs in China, and published dozens of related papers. He is a famous expert in pharmacokinetics and bioavailability research in Sichuan Province and enjoys a high reputation in the field of bioavailability evaluation of pharmaceutical preparations in China.
In the field of research and development, Professor Jiang Xuehua is responsible for the research and development of dozens of new drug pharmaceutics. Include naftopidil tablets, glimepiride capsules, amoxicillin/dichloropenicillin capsules, tazobactam sodium/piperacillin sodium for injection, compound calcium carbonate effervescent granules, etc.
Professor Jiang Xuehua strongly advocated clinical pharmacy education and clinical pharmacy working mode. Participated in the drafting and implementation of the first undergraduate teaching plan of clinical pharmacy in China. As the person in charge, he presided over the implementation of the research project of teaching reform of the Ministry of Education, the research project of teaching reform in Sichuan Province and a number of national continuing medical education projects, and made arduous explorations and carried out fruitful work in this field. Through the continuing education of clinical pharmacy in China, a large number of early clinical pharmacy talents in China have been trained, which has made positive contributions to the development of clinical pharmacy in China and published more than 0 related papers 10. He is a famous clinical pharmacy educator and one of the founders of clinical pharmacy in China.
Professor Jiang Xuehua has offered courses on biopharmaceutics and pharmacokinetics, clinical pharmacokinetics, modern evaluation methods of drugs, advanced pharmacokinetics, research methods of clinical pharmacy and research methods of pharmaceutical affairs management for undergraduates, master students and doctoral students. Director of the excellent course of pharmaceutical administration in Sichuan Province. In teaching practice, he constantly updated the teaching content and teaching methods.
New drug development:
"Naftopidil Tablets" 200 1 obtained the national first-class new drug certificate (preparation director); New drug certificate number: National Medicine Certificate x 200 10 137 (issuance date: 200 1.3. 14. )
"glimepiride and its capsules", in 2000, obtained the national second-class new drug certificate (preparation director); New drug certificate number: national medicine certificate word x20000529, x20000530 (date of issuance: 2000. 12. 15. )
"oxaliplatin for injection (freeze-dried injection)", 200 1 won the second prize of national new drug certificate (preparation director); New drug certificate number: National Medicine Certificate x200 10568 (issuance date: 200 1.9.6). )
"Amoxicillin/Dichloropenicillin Capsules", 1999, was awarded the national third-class new drug certificate (preparation director); New drug certificate number: National Medicine Certificate X 1990 109 (date of issuance: 1999.7.28). )
"Tazobactam Sodium for Injection/piperacillin sodium", 1999, was awarded the national third-class new drug certificate (director of preparation); New drug certificate number: National Medicine Certificate X 1990 143 (date of issuance: 1999.7.28). )
"Compound Calcium Carbonate Effervescent Granule", won the national third-class new drug certificate (project leader) in 2004; New drug certificate number: National Medicine Certificate H2004065 1 (date of issuance: June 24, 2004).
Patent application:
2005. 10.26. Invention patent: "Tanshinone solid dispersion and inclusion compound and their uses", published by People's Republic of China (PRC) and China National Intellectual Property Administration, with publication number of CN 1686 104A (the first inventor);
On March 26th, 2003, the invention patent was "Antibiotic composition with synergistic effect on β -lactamase resistant strains", which was published by People's Republic of China (PRC) and China National Intellectual Property Administration with the publication number of CN 1404834 (the fourth inventor).
Awards:
"Colorimetric determination of isoniazid and its metabolite acetyl isoniazid in urine and determination of acetylation metabolism in 35 cases of Han and Tibetan people" won the third prize of scientific and technological progress of the Ministry of Health (second main research)1988;
"Research on standardization of color inspection method of drug solution" won the third prize of Sichuan Science and Technology Progress Award (second main research)1992;
"Basic research on the new dosage form of nanoparticles in ophthalmology with norfloxacin as model drug" won the third prize of scientific and technological progress (the third main research)1999 from Sichuan Provincial Health Department;
"Basic Research on New Formulation of Ophthalmic Norfloxacin Nanoparticles", won the third prize of Chengdu Science and Technology Progress Award (the third main research) in 2000;
From June 5438 to February 2000, he was awarded the title of "Doctor with Outstanding Contribution in Sichuan Province" by the Academic Degrees Committee of Sichuan Provincial People's Government and the Education Department of Sichuan Province.
"Research and Practice on the Training Mode of Pharmaceutical Talents from 265438 to the Early 20th Century", won the first prize of teaching achievement of Sichuan University in 2004 (project leader);
"Research and practice on the training mode of 265,438+pharmaceutical talents in the early 20th century-research on the training mode of pharmacists", won the 11th Social Science Achievement Award of Sichuan Province in 2005, and was awarded the second prize (project leader) for outstanding achievements in social science by Sichuan Higher Education Society;
As the head of the vertical project.
National Natural Science Foundation Project: "Study on Quality Evaluation of Organ-targeted Nanoparticle Drug Delivery System for Anticancer Drugs". Approval No.39570842; 80,000 yuan; Commencement date: 1996. 1. - 1998.438+02.
representative works
Main papers published in recent three years
1. Pharmacokinetics of rifampicin combined with isoniazid, Huaxi Pharmaceutical Journal, 2003,18 (1):16;
2. Determination of ketoprofen in human plasma by HPLC, Huaxi Pharmaceutical Journal, 2003,18 (1): 50;
3. Hospital Pharmacy and Pharmaceutical Education in the New Era, Pharmaceutical Education, 2003,19 (1):1;
4. Discussion on in vitro and in vivo correlation test of sustained and controlled release preparations, China Medical Guide, 2003,5 (2):150;
5. Stability evaluation of thymopentin during preparation, Journal of Sichuan University (Medical Edition) 2003; 34(2):292;
6. Simultaneous determination of acetaminophen and caffeine in plasma by 6.RP-HPLC, Huaxi Pharmaceutical Journal, 2003,18 (2):110;
7. Pharmacokinetics of breviscapine in dogs, Journal of Pharmacy, 2003, 38 (5): 371;
8. Pharmacokinetics of fast full-dose nicotinic acid sustained-release tablets, China Hospital Pharmacy Journal, 2003,23 (3):129;
9. Pharmacokinetics of scutellarin in dogs, China Journal of Pharmacy, 2003,12 (3):127;
10. Effect of amoxicillin on pharmacokinetics of glimepiride in grass dogs, China Journal of Pharmacy, 2003,38 (3): 207;
1 1. Determination of sulfonylurea glimepiride in dog serum by reversed-phase high performance liquid chromatography with pre-column derivatization:, China Journal of Pharmacy, 2003,12 (2):101;
12. Study on Relative Bioavailability of Aspirin in Affin Card, Journal of Biomedical Engineering, 2003,20 (4): 661;
13. Pharmacokinetics of breviscapine in rabbits, Journal of Biomedical Engineering, 2003,20 (4): 692;
14. Bioequivalence evaluation of rifampicin in Yigan tablets, China Pharmacy, 2003,14 (7): 416;
15. Pharmacokinetics and Relative Bioavailability of Isofoamide Tablets, China Hospital Pharmacy Journal, 2003,23 (8): 475;
16. Study on extraction method of ginsenoside Re, Acta Botanica, 2003,23 (4): 667:
17. Discussion on setting the time limit for delaying blood donation after taking traditional Chinese medicine, China Journal of Blood Transfusion, 2003,16 (6): 389;
18. Effect of food on drug bioavailability, Journal of Fujian College of Traditional Chinese Medicine.2003.13 (6): 43;
The cost-benefit analysis of 19. 3 Treatment of neutropenia after radiotherapy and chemotherapy, China Pharmacy, 2003,14 (10): 601;
20. Formulation and in vitro adhesion determination of naftopidil bioadhesive sustained-release capsules, China Journal of Pharmacy, 2003,34 (9): 448;
2 1. Effect of amoxicillin on the plasma protein binding rate of glimepiride, Huaxi Pharmaceutical Journal, 2003,18 (4): 246;
22. Determination of total flavonoids, quercetin and isorhamnetin in Salix flavone acetate sustained-release capsules, Huaxi Pharmaceutical Journal, 2004,19 (1): 41;
23. Population pharmacokinetics theory and its application, China Pharmacy, 2004,15 (1): 50;
24. Determination of related substances in gatifloxacin preparation by HPLC, China Journal of Antibiotics, 2004,29 (3):146;
25. Determination of Urapidil in Plasma by RP-HPLC, West China Journal of Pharmacy, 2004,19 (2):119;
26. Determination of three tanshinones in dog plasma by RP-HPLC, Huaxi Pharmaceutical Journal, 2004,19 (2):121;
27. Pharmacokinetics of Naftopidil sustained-release capsules in dogs. 2004.5438+05 (5):
28. Study on Relative Bioavailability of Yifu Capsule, chinese journal of modern applied pharmacy Journal, 2004.21(2):132;
29. Study on intestinal absorption of glimepiride in rats, journal of third military medical university, 2004,26 (10): 886;
30. Preparation of thymosin capsules, China Hospital Pharmacy Journal, 2004,24 (8): 483;
3 1. Pharmacokinetics of cefoperazone and its compound preparation with tazobactam in dogs, China Pharmacy, 2004,15 (8): 469;
32. Study on in vitro release of freeze-dried injection of aclacinomycin A solid lipid nanoparticles, China Pharmacy, 2004,15 (9): 533;
33. Study on relative bioavailability and correlation in vitro and in vivo of Urapidil sustained-release capsules, China Journal of Pharmacy, 2005,40 (2):123;
Bioavailability of domestic secnidazole tablets and capsules, China Journal of Antibiotics, 2005, 30 (20):114;
35. Determination of release rate and release characteristics of fibrauretine sustained-release tablets, Huaxi Pharmaceutical Journal, 2005, 20 (2):113;
36. In vitro release of flavonoids from Salix psammophila, West China Journal of Pharmacy, 2005,20 (2):133;
37. Effect of Labrasol on intestinal P- glycoprotein function, West China Journal of Pharmacy, 2005,20 (2):139;
38. Discussion on the technical (access) conditions of clinical pharmacists, China Pharmacy, 2005,16 (7) 484;
39. Identification of pharmacokinetic model, China Pharmacy, 2005,16 (7) 525;
40. Pharmacokinetics of glutathione preparation, China Journal of Practical Chinese and Western Medicine, 2005,18 (13): 297;
Research progress of 4 1. P- glycoprotein and its inhibitors, China Pharmacy, 2005,16 (10): 787;
42. Determination of Anisodamine in Human Plasma by HPLC, chinese journal of pharmaceutical analysis, China, 2005,25 (8): 970;
43. Study on absorption mechanism of forsythin in rats, Huaxi Pharmacy, 2005,20 (5): 387;
44. Relative bioavailability of octreotide for injection, West China Journal of Pharmacy, 2005,20 (5): 414;
45. Discussion on the working standard of pharmacists in medical institutions (GPP), Huaxi Pharmacy, 2005,20 (5): 466;
46. Kinetic Study on the Ethanol Extract of Salvia Miltiorrhiza in Rats, China Chinese Herbal Medicine, 2005,36 (10):1480;
47. Research progress on the mechanism of intercellular penetration enhancers, Zhongnan Pharmacy, 2005,3 (6): 363.
48. Absorption characteristics of Panax Notoginsenoside R 1 and Ginsenoside Rg 1 in rat intestine. European Journal of Metabolism and Pharmacokinetics, 2005,30 (4): 261;
49. Pharmacokinetics of cytarabine nanoparticle freeze-dried powder injection in rabbits, Journal of Sichuan University (Medical Edition), 2006,37 (1):145;
50. Synthesis and characterization of PEG-scutellarin conjugate. A potential PEG ester prodrug for breviscapine oral administration, China Chemical Communication, 2006, 17( 1):85.
representative works
1. Editor-in-Chief: Introduction to Drug Evaluation Methods, Sichuan University Press, Chengdu, 2005;
2. Participated in compiling the 2nd edition of New Drug Formulations and Technologies, Beijing, People's Health Publishing House, 2005;
3. Participated in compiling: Biopharmaceutics and Pharmacokinetics, Beijing, People's Health Publishing House, 2003;
4. Participated in compiling: Targeted Drug Delivery Preparations, Sichuan Science and Technology Press, Chengdu,1997;
5. Participated in compiling: Practical Clinical Pharmacokinetics, Sichuan University Press, Chengdu,1997;
6. Deputy Editor-in-Chief: Handbook of National Basic Medical Insurance Drugs, Labor and Social Security Press, Beijing, 2001;