As contemporary college students in the new century, if they want to do something, they must take the historical mission of the times as their own responsibility, grasp the pulse of the times, keep up with the source of development, meet the challenge of change, and thus establish their lofty aspirations to contribute to the development of the times and human progress. 1, the sacred mission is to realize the great rejuvenation of the Chinese nation. The Chinese nation has a long history and has long been at the forefront of human civilization. However, in the tide of modern civilization, China gradually fell behind the times and even became a backward thug. Today, the sacred mission of realizing the great rejuvenation of the Chinese nation has historically fallen on the shoulders of contemporary college students. We contemporary college students should actively invest in realizing the great rejuvenation of the Chinese nation. 2. Take promoting a well-off society in an all-round way and building a harmonious socialist society as a historical task. Building a well-off society in an all-round way and building a harmonious society are two concrete manifestations of China's socialist modernization. This is also an unshirkable historical responsibility entrusted to contemporary college students by the times. 3. The basic requirement is to improve the comprehensive quality of college students. Only by improving their comprehensive quality can we adapt to the requirements of the rapid development and changes of the times and shoulder the historical mission and social responsibility entrusted by the times.