Since 1996, under the guidance of Professor Tang Beisha from the Department of Neurology of Xiangya Hospital and Academician Xia Jiahui from the State Key Laboratory of Medical Genetics, he has been focusing on the clinical and genetic research of hereditary diseases of the nervous system, especially hereditary spinocerebellar ataxia and hereditary spastic paraplegia. As a main member, he participated in the National Natural Science Foundation project "Isolation of ataxia protein -3 interacting protein and its relationship with hereditary ataxia" (FundNo. :30070273)， In 2004, it was awarded the National Natural Science Foundation's project "Localization and Cloning of New Hereditary Paraplegia Pathogenic Genes" (project approval number: 30300 199). The completion time: 65438+2004 10 ~ 65438+February 2004), a new type of SPG30. Kloc-0/4.50039.000000000065 won the second prize of scientific and technological progress in Hunan Province and the first prize of medical and health scientific and technological progress in Hunan Province in 2005, which was supported by the National Natural Science Foundation.