I'll just say this, because my research direction during my master's degree is chiral groups and chromatography, especially GC and LC. Yuan Liming Research Group of Yunnan Normal University should do a good job in chiral gas chromatography columns in China. Previous work was based on cyclodextrin or cellulose derivatives, and then many chiral gas chromatography stationary phases were made. The first article is about him and his doctoral student Xie. The DOI published by JACS is10.1021/JA 204453, and then there are articles on chiral stationary phases in liquid chromatography and capillary electrophoresis. See the brief introduction of Yuan Liming Research Group: Cyclodextrin (CD for short) has more than six D-(+)- glucose molecular units through α-65438. The most commonly used α-β-γ-cyclodextrin contains six, seven and eight glucose units respectively. There are five chiral centers on each glucose unit. The shape of cyclodextrin is hollow frustum, in which the inner cavity diameter of β -cyclodextrin is 0.65 nm and the outer diameter is 1.53nm. The hydroxyl group on C(6) (the sixth carbon on the glucose unit, the same below) is located at the narrow end of the cavity, pointing counterclockwise, while the hydroxyl groups on C(2) and C(3) are located at the wide end of the cavity. Therefore, the lumen has only C-H bond and C-O glycoside bond, which is hydrophobic. The ring has polyhydroxy groups and is hydrophilic. The isolated surface of O atom faces the inner cavity, which makes the inner cavity have higher electron density, has the characteristics of Lewis base, and can form inclusion complexes with many compounds. This structural factor plays a role in chiral recognition. At present, it has developed into the most important subject of supramolecular chemistry, which is of great significance to promote the development of life science and pharmaceutical science. Since cyclodextrin and its derivatives were used to separate enantiomers in 1987, more than 50 cyclodextrin derivatives have been synthesized and used as gas chromatographic stationary phases, and hundreds of chiral compounds have been separated. At present, new cyclodextrin chiral stationary phases have been synthesized and widely used in the separation of enantiomers in high performance liquid chromatography (HPLC) and capillary electrophoresis (ce). Because of the high melting point of cyclodextrin and some derivatives, it is difficult to coat on the capillary wall. Many people dissolve them in moderately polar polysiloxane (such as OV- 170 1) to form mixed stationary liquid.