Shunerning is a leukotriene receptor antagonist with strong selectivity, which is suitable for the treatment of asthma in adults and children, and can also be used to treat allergic rhinitis and allergic rhinitis asthma syndrome. Its chemical name is Montelukast. At present, it is widely used in China to treat cough and asthmatic asthma caused by respiratory allergy in children. There are reports of adverse reactions such as allergic drug sensitization. The clinical efficacy and side effects of Shunerning are described below:
(1) efficacy evaluation
The dose of Shuerning 10 mg is more effective than placebo. The results of another similar experiment showed that the PEFR of patients with chronic asthma increased after the application of 10 mg of Shunerning, and the number of acute attacks of asthma decreased significantly after the application of 10mg and 50mg of Shunerning. In addition, the daytime symptom score, the inhalation of β2 receptor agonists (such as salbutamol) and the quality of asthma-related sexual life in the control group were significantly relieved.
The comparative study of the three dosage groups of Shunerning (2mg, 10mg and 50mg) found that the symptom control of patients with chronic asthma in the dosage groups of 10mg and 50mg was obviously better than that in the dosage group of 2mg, suggesting that its curative effect was dose-dependent.
Long-term treatment (March) with a single dose of Sunanin( 10mg// day) also proved to be effective in treating asthma attacks. Compared with beclomethasone dipropionate (400μg/ day) in March, FEV 1.0 increased by 65438 after Shu Ning treatment. NbspFEV 1.0 increased 16.3%, and the daily dose of β2 receptor agonist decreased by 35.6% and 37.7% respectively.
Shunerning is also effective in treating allergic cough's disease, cough variant asthma and bronchial asthma in children aged 6 months to 14 years, but there is no significant difference between the two groups in the symptoms of cough and asthma during the day, PEFR in the morning and evening, waking up at night and the days of suspension from school.
(2) Side effects
On March 27th, 2008, the US Food and Drug Administration (FDA) issued an announcement [Announcement 03/27/2008] to medical staff and patients, arguing that the use of Shunerning may cause behavioral/emotional changes and suicidal tendencies and behaviors. At present, parents have reported that their children become irritable after taking Shunerning for three months. Parents of allergic children who take Shunerning should closely observe and report to the doctor in time once they find that their children's behavior/mood has changed. For children who take medicine, we should pay attention to whether the child will be active, inattentive, aggressive, sleepy and depressed.
In 2009, after investigation, FDA officially stated that three asthma drugs, such as Shunerning, may cause mental problems, and relevant manufacturers need to highlight the drug risks on the drug labels. The FDA issued a statement on its website, pointing out that some consumers who took "Shuerning", "Ackroyd" and "Zileton" had depression, anxiety and suicidal tendency. The FDA investigation confirmed that these three asthma drugs may cause mental problems. The FDA said that both doctors and patients need to be aware of the potential risks of these drugs to mental health.
(3) What about asthma in allergic cough?
1, actively looking for allergens. It is common to inhale some plant pollen, indoor dust, mites, fungal spores, animal dander, fish and shrimp in food or in contact with paint dyes. Before each cough attack, carefully observe what factors exist, find out the allergic factors, avoid them and prevent contact again.
2. Avoid incentives. There are three possible reasons for cough variant asthma attack: first, climate change, high incidence in winter and spring, and cold air stimulation as the main reason, so it is necessary to do warm protection, especially to wear warm clothes and masks when going out in the early morning of winter; Second, the cough is aggravated after exercise, and children with such asthma should avoid strenuous exercise; Third, emotional excitement and crying can also induce cough attacks, so try to make your child emotionally stable.
3. Enhance the immune function of the body. The essence of cough variant asthma is asthma, and asthma is an allergic disease, that is, allergic reaction caused by abnormal immune function, so we should pay attention to improving and enhancing the immune function of the body. At present, Kangminyuan enhanced version, a special anti-allergic probiotic preparation for adjusting allergic constitution and enhancing anti-allergic ability, has been widely used. Using this simple and safe anti-allergic immune enhancer has greatly improved the prevention and treatment effect of asthma in allergic cough.
4. The principle of treating cough variant asthma is the same as asthma, because the pathogenesis is the same as asthma, and there are pathological changes of chronic allergic inflammation and airway hyperresponsiveness. Therefore, long-term use of controlled drugs-inhaled sex hormones or leukotriene receptor antagonists can achieve better curative effect, and the course of treatment can be shorter than that of asthma. Although the anti-inflammatory effect of leukotriene receptor antagonist is not as strong as that of hormone, it can be recommended for children who are unwilling to use inhaled hormone or whose condition is mild. At present, drugs such as Shunerning are commonly used to control the symptoms of respiratory asthma in allergic cough for a long time, and they are also used together with inhaled glucocorticoids (such as pulmicort and fluoxetine). However, because these treatments only treat the symptoms, they are not suitable for long-term inhalation, and they really rely too much on the control of anti-allergic drugs to stop taking drugs. As long as the drug is stopped, it will recur or aggravate the cough and cause asthma. Failure to cooperate with immunotherapy or radical measures is also an important reason why many children with asthma rely on inhaled sex hormones for a long time and cannot stop taking drugs or drugs.
5. The antiallergic effect of Kangminyuan, an antiallergic probiotic, on allergic cough in children;
The results of microbial research have attracted the attention of clinicians, and many papers have been published on microorganisms and allergic diseases, intestinal microorganisms and childhood asthma, respiratory microorganisms and childhood asthma, and the preventive and therapeutic effects of probiotics on childhood asthma. For allergic diseases, it is no longer at the therapeutic level of antiallergic drugs and hormone atomization. Man is a "superorganism", and some intractable diseases are expected to make therapeutic breakthroughs in the study of human organisms in the near future. The human genome and microbiome work together to influence the immune, nutritional and metabolic processes of human body. Kang Minyuan's anti-allergic probiotics focused on the research of anti-allergic probiotics strains and formulas for eight years, and regarded the efficacy of formulas and the quality of strains as the lifeline. Combined with Professor Wang Zhiyao from national cheng kung university Allergy and Clinical Immunology Research Center in Taiwan Province, the clinical experimental case study showed that antiallergic probiotics affected the occurrence and development mechanism of allergic diseases immune system, and created an antiallergic nutritional therapy with Kangminyuan antiallergic probiotics. Supplementing Kangminyuan antiallergic probiotics can: regulate the steady state of respiratory tract microbial flora and relieve cough and asthma caused by airway hyperresponsiveness; Adjust the homeostasis of intestinal microbial flora and improve the allergic mechanism of intestinal food protein; Regulate the allergen-specific IgE pathway mediated by intestinal microecological flora and inhibit the production of allergen-specific IgE antibody.
Children with cough and asthma should be supplemented with Kangminyuan probiotics, which is a compound antiallergic probiotic component and can participate in the regulation of immune cytokines. This rare anti-allergic probiotic can promote the secretion of interferon in vivo, so as to regulate TH 1 immune response and resist immunoglobulin IgE. By enhancing the TH 1 immune response of immune cells, TH2 immune response overreacted due to allergy can be regulated, thus improving children's anti-allergic ability. This safe Kangminyuan probiotic anti-allergic immune intervention regulation therapy can greatly reduce or shorten the course of anti-allergic western medicine, regulate immunity and reduce allergies.
It is suggested that the formula of antiallergic probiotics should be selected through clinical trials and thesis research.
The clinical study of Kang Minyuan's anti-allergic probiotics and the pediatric team of Xijing Hospital was successfully accepted two years later. These two research papers are published in international journals, focusing on the mechanism of allergy protection. It is found that anti-allergic probiotics can induce the generation of CD 103+ dendritic cells, thus regulating the generation of T lymphocytes, promoting immune balance and reducing the risk of food allergy and airway inflammation.
Paper 1: Study on the Protective Mechanism of Kangminyuan Allergic Probiotics on Food Allergy.
Source: Functional Food Journal (SCI impact factor: 3.47)
Kangminyuan anti-allergic probiotics can reduce the contents of IgE and IgG in serum, promote the production of IgA, inhibit the symptoms of food allergy, induce the production of dendritic cells (DCs) of CD 103+, promote the production of regulatory T lymphocytes (Treg), promote the intestinal immune balance, and help to adjust allergic constitution.
Paper 2: Study on the protective mechanism of Kangminyuan anti-allergic probiotics on airway inflammation.
Paper source: J Shanxi Medical University?
Kangminyuan antiallergic probiotics can improve airway allergic inflammation, reduce the number of inflammatory cells (eosinophils, neutrophils and lymphocytes) in alveolar tissue, relieve chronic airway inflammation, induce the production of Treg cells in lung lymph nodes, promote the expression of related inhibitory cytokines IL- 10, inhibit the expression of Th2 cytokines, play an immunomodulatory role, and inhibit allergic inflammation caused by antigens, which has a good effect on airway inflammation.