JACS is recognized as the top international journal in the field of chemistry, and its papers cover chemistry, materials, physics, life sciences, biomedicine and other fields. The first author of this paper is College of Bioengineering, Chongqing University, and the corresponding authors are professors Wei and Gazit.
As the core recognition sequence of amyloid protein, Diphenylalanine Dipeptide (FF) has the advantages of super self-assembly, diverse assembly structures and easy modification of molecular functions, and has become one of the most widely studied short peptide derivative sequences in the fields of biology and nanotechnology.
Wiki research group of Chongqing University
In 2022, Ji Wei Research Group of Chongqing University cooperated with Wei Research Group of Fudan University and Ehud Gazit Research Group of Tel Aviv University, and jointly reported that diverse bipyridine derivatives can be prepared by multistage assembly of N-terminal modified FF dipeptide derivatives (ZFF, BocFF, AcFF).
In addition, the construction of multi-response supramolecular hydrogel was realized. In this work, molecular dynamics simulation is used to further study the morphological structure transformation induced by molecular * * * assembly, which is helpful to understand the mechanism of multi-stage * * * assembly process.