Previously aspirin was mostly used to reduce fever and relieve pain. It is often taken when you have a cold. Later, it was found to have the effect of inhibiting thrombosis. Now it is used to prevent cardiovascular and cerebrovascular diseases. The latter is the main purpose that people in their forties and fifties take every day. Some recent studies show that a considerable number of people are free from cancer after taking aspirin, especially digestive tract tumors, especially colorectal tumors. This research result was recently published in the American journal JAMAOncology. This result comes from two large cohort study groups in the United States, who used aspirin to treat headache, arthritis, musculoskeletal pain and prevent cardiovascular diseases.
The results show that compared with people who take aspirin irregularly, the overall cancer incidence of regular users decreases, especially colorectal cancer. In order to achieve this benefit, aspirin needs to take 0.5- 1.5 tablets per week, and it takes more than 5 years to observe the obvious anti-cancer effect.
Previously, the prevention of colorectal cancer depended largely on endoscopic screening. This study suggests that taking aspirin regularly can prevent 33/65438+ 10,000 people from developing colorectal cancer every year among participants over 50 years old and those who have not undergone lower gastrointestinal endoscopic screening. Taking aspirin regularly can prevent 18/65438+ 10,000 people from developing colorectal cancer every year. Obviously, routine endoscopy and aspirin are dual means for early prevention and detection of colorectal cancer, and they complement each other. According to the cancer prevalence rate in the United States in 20 15 years, 29,800 people will be saved from gastrointestinal tumors every year by taking aspirin, which is equivalent to 25% of the cancer-related mortality rate in the United States.
People are used to thinking that aspirin is harmful to the stomach. For this reason, enteric-coated aspirin has been available, but when can enteric-coated aspirin really protect gastric mucosa? A common misunderstanding is that you should eat it with or after meals. Actually lost the value of "enteric".
The so-called "enteric dissolution" means that it will be dissolved and absorbed under the pH condition of the intestine, but the pH of the stomach and the intestine is definitely different. Gastric acid is a strong acid, and enteric aspirin is basically insoluble in acidic environment. It must be after the duodenum that the PH value rises before it begins to dissolve. However, if aspirin is taken after meals, the retention time of aspirin in the stomach will be prolonged, the PH value in the stomach will also increase after meals, and the drug retention time will become longer. The more aspirin precipitates, the easier it is to hurt the stomach. So as long as it is marked "enteric-coated", you must take it before meals! Aspirin prevents platelet aggregation and thrombosis. However, during the period from 6: 00 am to 10, the blood viscosity is high. Generally speaking, after taking aspirin, the drug concentration in blood vessels can reach the peak at 1-2 hours, and the absorption of aspirin "enteric-coated tablets" is slightly delayed, and the concentration reaches the peak at about 3-4 hours. So the best time to take aspirin is to get up in the morning and take it when drinking water for the first time.