Many foreign scientific papers of NMN have confirmed its anti-aging effect. Starting from the latest anti-aging scientific research achievements in Professor Sinclair's laboratory of Harvard University, Rivetto is the transformation of this achievement.

A few days ago, a joint research team of Keio University in Japan and Washington University in the United States revealed that the results of the first phase of human clinical trials of β -nicotinamide mononucleotide (NMN, one of the key components of Harvard's "longevity drug" Revitor introduced by Herbalmax Company in the United States) were positive, and follow-up trials are currently underway. Previous studies have confirmed that NMN, the core component of Revitor, as the precursor of NAD+, an important coenzyme in human body, can rapidly increase the level of NAD+ after entering human body. NAD+ is not only an important raw material for DNA repair system in cells, but also a key contact factor between the nucleus and mitochondria responsible for energy synthesis. Supplementing NAD+ is also an oral NAD+ supplement for Herbalmax Revitor NMN (Revitor Basic Edition is sold in 650 yuan on Tmall, JD.COM and Suning platforms). The research data show that oral administration of NMN contained in river can effectively compensate for the decrease of NAD+ content in vivo caused by aging, and the recovery of NAD+ brought by NMN in Herbalmax Rivetor can prolong the life span of experimental animals similar to humans by as much as 1/3.

In March 20 16, the clinical trial officially started. 10 A healthy male aged 40-60 was given NMN with an oral dose close to that of Herbalmax Rivetor for 6 months. At the same time, 30 indexes such as blood, body temperature and blood pressure were measured by the monitor, and the clinical data of NMN, the core component of riveter, was monitored. The research team disclosed that it will take at least several years of research and observation to further track and confirm the data of taking oral NAD+ supplement of NMN herbal max Revito delay the decline of physical function caused by aging.

In February, 2065438+2009, the interim report of the clinical trial "Effects of long-term (24 weeks) oral administration of NAD+ precursor NMN on human body" was published for the first time. The report of this achievement shows that the expression of Sirtuins family (a longevity protein) is increased after oral administration of NMN NAD+ supplement capsules close to Herbalmax Rivetor. Since 1990s, Leonard Guarente, a biology professor at MIT, has been working in his laboratory to study the relationship between aging and Sirtuins. His research shows that sirtuins play an important role in delaying cell apoptosis and aging, so they are called anti-aging proteins or longevity proteins.

Imai Shinichiro emphasized that NAD+ precursor NMN, the core component of Herbalmax Revitor, is not a "panacea", which can neither make people live forever nor completely inhibit human aging. The role of NAD+ precursor NMN in Revitor is to prolong the "healthy life", that is, to prolong the life of people who can keep young and healthy even when they are old.

However, before Herbalmax went public, the consumption cost of NAD+ precursor NMN was relatively high (more than 6.5438+0.5 million yuan per person per year), and NAD+ precursor NMN almost became synonymous with the rich in the past few years. Until 20 18, Herbalmax, an American biotechnology company, reduced the price of NMN by more than 90% by using biological enzyme catalysis technology, and launched it under the brand of Revitor (Chinese name: Revitor). Only then did it complete the mature oral NAD+ supplement for NMN, and put it into practical use for the first time through Revitor, and then launched a more universal "Revitor Basic Edition" (Tmall, Revitor).

Since 20 18, Herbalmax has been introduced to China from JD.COM, Suning and Tmall. Although the price of NMN oral NAD+ supplement Rivetto discouraged most consumers in China, Rivetto started to snap up from the beginning and sold out frequently, which even triggered the panic of domestic health care products manufacturers about Rivetto products and the crazy cottage of NMN oral NAD+ supplement.

From 2065438 to September 2009, McLane, a global supply chain giant owned by Warren Buffett, reached a strategic cooperation with Herbalmax, a manufacturer of Rivetor, which further promoted the popularization of Rivetor in the world, and launched the "Rivetor Core Edition" with a more universal price, further reducing the price of Rivetor, an oral NAD+ supplement product for NMN, to US$ 250 (Tmall, Suning, JD.COM) COM)。