If tuberculosis continues to be positive after 5 months of initial treatment, it is a failure of initial treatment, and it is possible to be resistant and refractory clinically. We should change the scheme test, carry out repeated sputum tuberculosis culture and drug sensitivity test, and clearly confirm the possibility of drug-resistant and refractory tuberculosis. If drug-resistant tuberculosis is diagnosed, the difficulty of treatment will increase accordingly, the cost will increase and the course of treatment will be prolonged. With the standard long-term anti-tuberculosis combined with multi-drugs and combined interventional therapy, the cure rate is relatively improved, mostly above 50%. However, there are individual differences, mostly depending on the drug resistance spectrum and whether it can be adhered to in treatment, and whether there are toxic or side effects. For details, please refer to my related articles (selected papers). At present, drug-resistant pulmonary tuberculosis patients are paid more and more attention in the world and China. The "Tenth Five-Year Plan" and "Eleventh Five-Year Plan" respectively set up special projects and funds for major infectious diseases of drug-resistant tuberculosis. Our hospital has participated in many projects, and the treatment effect of some patients is not bad. You should be prepared to "attach importance to her strategically and despise her ideologically" and cooperate with the doctor's treatment. Chest tightness has little to do with the side effects of drugs. It should be the widespread invasion of your lung lesions and the impact on lung function.