① 198 1 year, the first human frozen sperm bank was established in China to provide healthy sperm for men with azoospermia and severe genetic diseases, and the first artificial insemination baby with frozen semen was born in 1983. Sperm bank and artificial insemination technology better meet the fertility requirements of men with serious genetic diseases, azoospermia and sterilization, as well as the needs of male reproductive insurance.
② The abnormal sperm separation technique was established to screen healthy sperm for azoospermia patients. 199 1 year, the normal artificial insemination infant with abnormal sperm separation was reported for the first time in the world.
③ 198 1 year, China started the research on human in vitro fertilization, and the first test-tube baby was born in Hunan province in 1988. She put forward the idea of "embryo transfer" to provide healthy embryos for patients with genetic diseases and elderly women, and gave birth to the first embryo transfer test-tube baby in China on 1988.
④ By improving the method of embryo cryopreservation, the ultra-fast embryo cryopreservation technology was established, and in 2000, the first ultra-fast frozen embryo transfer test-tube baby in China was born.
⑤ A new technique of mouse sperm micro-fertilization was established for the first time in China, and it was applied to clinic in 1997, and achieved good results. 1999, micro-fertilization was further combined with blastocyst culture, and a blastocyst-cultured IVF was born.
⑥ Combining reproductive medicine with genetic medicine, through pre-pregnancy diagnosis, the vertical transmission of genetic diseases in the family line can be blocked. In 2005, the first normal baby born in China after the pre-implantation diagnosis ruled out progressive muscular dystrophy was born.
⑦ Pay attention to the application and innovation of scientific research results in clinical work, and constantly improve the success rate of assisted reproduction and pregnancy.
She is one of the founders of reproductive engineering in China. She has won seven national first prizes in scientific research and seven national and provincial scientific and technological progress prizes. Become an academic leader with high reputation in the field of reproductive genetics in China, a young and middle-aged scientific and technological expert with outstanding contributions from the country, and an expert enjoying special state allowances;
She has published three monographs on human reproduction and reproductive engineering.
She has been supported by key projects of National Natural Science Foundation, National 973 Project, National Key Scientific and Technological Project, China Medical Association Foundation (CMB) and many other projects. He has published 456 papers, including 1 18 papers in SCI magazine and 6 monographs, and obtained 8 national utility model patents. The key technologies of human assisted reproduction and sperm bank led by her and their application in reproductive health won the second prize of 1989 and the National Science and Technology Progress Award in 2009 respectively, becoming the only two in the field of human assisted reproduction in China.