Ralph Baric, male, professor of epidemiology at the University of North Carolina, USA, is known as the father of coronavirus.
1989, barrick published a study on viral gene recombination. In 2003, barrick cloned an infectious SARS virus strain in the biological laboratory of Fort Detrick. In 2004, barrick's team began to study the reverse genetics of SARS virus, which has been supported by the National Institutes of Health for many years.
On June 25th, 2008, barrick published the paper "Synthesis and recombination of SARS-like coronavirus is contagious to cultured cells and laboratory mice", and introduced the strength of his team: now we have the ability to design and synthesize various SARS-like coronaviruses. 2015165438+10. In October, barrick's team published a paper saying that they had successfully manufactured a chimeric virus, which was contagious to human cells.
Characteristics of novel coronavirus's disease
According to the existing case data, novel coronavirus is mainly characterized by fever, dry cough and fatigue, and a few patients are accompanied by symptoms of upper respiratory tract and digestive tract such as nasal congestion, runny nose and diarrhea. Severe cases often have dyspnea after 1 week, and severe cases quickly progress to acute respiratory distress syndrome, septic shock, refractory metabolic acidosis, bleeding and coagulation dysfunction and multiple organ failure.
It is worth noting that severe and critically ill patients may have moderate to low fever or even no obvious fever during the course of the disease. Mild patients only show low fever and mild fatigue. , and no pneumonia. Judging from the cases admitted at present, most patients have recovered well, and a few patients are in critical condition. The prognosis of the elderly and those with chronic basic diseases is poor. The symptoms of children's cases are relatively mild.