The water produced by varicella virus Oka strain provided by Institute of Microbiology (BIKEN) of Osaka University in Japan was observed.

Stability, safety and immunogenicity of live attenuated poxvirus vaccine. Methods according to the requirements of who regulations, the main seed batch and working seed batch were established and tested

The biological characteristics of the virus and the stability of the vaccine were determined. Clinical trials were conducted in Shanghai and Jiangsu province, and 468 patients aged 2-6 were vaccinated with five batches of vaccines.

The adverse reactions of vaccinated children were observed, and the positive conversion rate and geometric average titer of antibodies were determined. Results Oka varicella virus was detected in 2005.

MRC 5 cells were uploaded to 1O generation, and their biological characteristics were similar. After the vaccine was stored at 2 ~ 8℃ for 2 years, the virus titer decreased by 0.3 ~ 0.5 lgpfu/

Special agent. The incidence of rash in susceptible children after vaccination was 0.21; The reaction rates of low heat, moderate heat and high heat are 265438 0.79, 65438 0.68 and 0.64 respectively. antibody

The average positive conversion rate is 92. O3。 Conclusion The quality of live attenuated varicella vaccine is equivalent to that of similar products abroad, and it is safe for susceptible children.

It has good integrity and immunogenicity and should be popularized and applied.

Preparation of live attenuated varicella vaccine and observation of its immune effect. Download link of pdf:/files/ac1f27d1-E8E8-1dc-bb48-0014221f4662/