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Objective To explore the relationship between plasma D- dimer (DD) and schizophrenia. Methods The plasma DD content of 3 1 middle-aged and elderly female schizophrenics was detected by latex particle method, and compared with that of 25 female normal persons (control group) without a history of mental illness and cerebrovascular disease. Results The plasma DD content in schizophrenia group [(65438 0.38) 65438 0.02) mg/L] was higher than that in control group [([(0.665438±0.25)mg/L]/L], P
Schizophrenia; D- dimer
Studies have confirmed that schizophrenia is closely related to hyperviscosity syndrome (HVS) [1]. D- dimer (DD) can be used as a molecular marker of hypercoagulability and fibrinolysis in vivo [2], which is a peptide segment degraded by cross-linked fibrin D region, mainly composed of D(α), D(β) and D(γ)- D(γ) chains in D region, which can affect the aggregation function of red blood cells and regulate the biosynthesis of hepatic fibrinogen [3]. In order to explore the relationship between them, we detected the plasma DD content of female schizophrenics over 40 years old who were hospitalized in our hospital from September 19971June 1998 1438, and compared it with normal people. The results are reported as follows.
Objects and methods
I. Objection
1. Schizophrenia group: * * * 31case, all of which meet the diagnostic criteria of schizophrenia in China's mental illness classification scheme and the diagnostic criteria revised in the second edition [4], with BPRS score ≥38. In order to exclude the influence of age and gender on the research results, 3 1 cases were all women over 40 years old. The age of the patients ranged from 40 to 76 years, with an average of (57 9) years. The course of disease is 3 months to 17 years; No signs of cerebrovascular disease were found on CT or MRI of the head. 3 1 case, 12 cases did not take any psychotropic drugs before the first blood collection, and the rest 19 cases stopped taking psychotropic drugs >: 7 days; 365,438+0 cases were divided into two groups, with positive symptoms (hereinafter referred to as positive, SAPS)≥28, SANS ≤ 65,438+02) and negative symptoms (hereinafter referred to as negative, SAPS ≥ 30, SAPS ≤ 65,438+00).
2. Control group: * * There are 25 female employees in our hospital, with no history of mental illness or cerebrovascular disease, aged 42-78 years, with an average of (58 12) years. Did not take any psychotropic drugs before blood collection 1 month.
Second, the method
All subjects took blood on an empty stomach before 9: 00 in the morning, and sodium citrate was anticoagulated. Plasma DD content was detected by latex particle method and imported colloidal gold standard method kit (provided by Nanjing Hongyang Biotechnology Co., Ltd.), and the normal reference value was
result
The plasma DD content in schizophrenia group [( 1.38 1.02) mg/L] was higher than that in control group [(0.6 1.25) mg/L], t=3.6 1 1, P.
discuss
DD is a specific degradation product of fibrinolytic monomer crosslinked by activating factor XIII(FXIIIa) and hydrolyzed by fibrinolytic enzyme. The increase of DD level reflects the enhancement of secondary fibrinolytic activity, which can be used as one of the molecular markers of hypercoagulability and fibrinolysis in vivo [2,5]. In recent years, a large number of basic and clinical research results on DD show that the plasma DD content of patients with ischemic cerebrovascular disease increases and improves with the improvement of the disease. Detection of plasma DD content is helpful for diagnosis, curative effect observation and prognosis judgment of thrombotic diseases [5, 6]. At present, there is no report about the relationship between mental illness and plasma DD content at home and abroad. In this study, the plasma DD content of schizophrenic patients was higher than that of the control group (P
The results also showed that the plasma DD content in positive group was higher than that in negative group (P
Because the etiology of schizophrenia is still unknown, whether the plasma DD content can be used as one of the detection indexes to judge the recurrence, prognosis, observation of the evolution of the disease and treatment effect of schizophrenia needs to be further discussed by expanding the sample.
refer to
1, Huang Cheng, Shao Shengli, Liu Zhenqing. Application of hemorheology in the treatment of schizophrenia. Sichuan mental health,1996,9:139-140.
2, Fisher M, Francis R. Changes of coagulation function during cerebral ischemia. Arch nerve,1990,47:1075-1081.
3. Wang Jian, Li Jianzhang. DD and ischemic cerebrovascular diseases. Foreign medical cerebrovascular diseases, 1996, 4: 74-77.
4. Psychiatry Branch of Chinese Medical Association, Brain Hospital of Nanjing Medical University. Classification scheme and diagnostic criteria of mental disorders in China (CCMD-2-R). Nanjing: Southeast University Press, 1994.56-6 1.
5, Huang Weiguo, Zhang, et al. Detection of plasma DD and its clinical application. Chinese Journal of Medical Laboratory, 1995, 18: 7 1-74.
6. Guo and Zhao Huiyuan. Changes and clinical significance of plasma DD and GMP- 140 in patients with ischemic cerebrovascular disease. Journal of Clinical Neurology, 1996, 9: 202-205.
7. Wang Songju. Preliminary study on hemorheology of schizophrenia. Journal of Clinical Psychiatry,1997,7:103.
8. Zhu. Experience of promoting blood circulation and removing blood stasis in neuropsychiatry. Journal of Practical Chinese Medicine, 1996, 10: 17- 18.
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