195 1 year, james dewey watson came to Cambridge. They were all interested in how to store genetic information in molecular structure, and then they collaborated. They noticed the work of Avery, hershey, Chase and others, and locked their work objects in the structure of DNA. They think it is possible to guess a good molecular structure that can explain this problem.
195 1 year 1 1 month, maurice wilkins came to Cambridge University and provided the double helix structure of DNA discovered by him and his colleague Alexander Stokes from the experimental results of X-ray diffraction.
At the beginning of 1952, Crick asked Griffith to try to calculate the gravitational force between different nucleotides with basic chemical principles and quantum mechanics. Griffith's results show that guanine (G) and cytosine (C) attract each other, while adenine (A) and thymine (T) are the same pair. Crick didn't realize the importance of this result at this time.
1at the end of 952, Xia Jiaer came to England to meet Watson and Crick, and told them his new discovery, that is, Xia Jiaer's law (also known as base equivalence law). This rule contains two proportions: the ratio of guanine (G) to cytosine (C) is 1: 1, and the ratio of adenine (A) to thymine (T) is 1: 1, which is the same as Griffith's calculation.
Watson later suddenly realized that the structure of A:T pair is very similar to that of C:G pair. They are all of the same length, and the two molecules in each pair are connected by hydrogen bonds. Watson and Crick completed the research on the molecular structure of DNA after synthesizing the findings of Chakov and others. Watson and Crick first published their research results in Nature on April 25th, 1953. They used "photo 5 1" in their paper.