This research was led by Professor Yongfeng Shang, a member of the Department of Life Sciences and Medicine of China Academy of Sciences and the School of Basic Medicine of Peking University. Academician Yongfeng Shang is a famous biochemist and molecular biologist in China. The main research directions are epigenetic mechanism of gene transcription regulation and molecular mechanism of sex hormone-related gynecological tumors. Immunoprecipitation (Chip) technology of mammalian cell chromatin was established for the first time in the world, which made an important contribution to the study of the interaction between DNA and protein. Research papers have been published in top academic journals such as Cell, Nature and Science for many times.
Breast cancer is one of the most common malignant tumors in women, which usually occurs in mammary epithelial tissue, accounting for 7- 10% of all kinds of malignant tumors in the whole body. It is one of the most common malignant tumors, which seriously affects women's physical and mental health and even endangers their lives. Under the action of many carcinogens, breast epithelial cells have undergone gene mutation and/or epigenetic changes, leading to uncontrolled cell proliferation, and metastasis is the main cause of their death. Because angiogenesis is the key step and necessary condition of tumor growth and metastasis, inhibiting angiogenesis has also become an important method to treat tumor growth and metastasis.
In this paper, researchers used bioinformatics, molecular biology, cell biology and other means to study the biological function of histone demethylase Jarid1b. The researchers found that JARID 1B is a new component of the inhibitory complex NuRD, which can synergistically remove H3K4 hypermethylation with the LSD 1 subunit sequence of NuRD complex, and inhibit the expression of chemokine CCL 14 together with other components, thus inhibiting breast cancer cell metastasis and angiogenesis.
This new study not only reveals the biological activity of JARID 1B in inhibiting breast cancer metastasis and angiogenesis, but also discusses the possible cellular and molecular biological mechanisms of its action. The study of JARID 1B provides a possible target for the treatment of breast cancer, and also deepens our understanding of the complex and accurate regulation process of cells at the transcription level.